{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:00:03Z","timestamp":1792418403026,"version":"4.4.0"},"reference-count":146,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32220103006"],"award-info":[{"award-number":["32220103006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271524"],"award-info":[{"award-number":["82271524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Dementia can impose a heavy economic burden on both society and families. Alzheimer's disease (AD), the most prevalent form of dementia, is a complex neurodegenerative disease characterized by the abnormal deposition of extracellular amyloid \u03b2\u2010protein (A\u03b2) and the aggregation of intracellular Tau protein to form neurofibrillary tangles (NFTs). Given the limited efficacy of pharmacological treatment, scientists have already paid more attention to non\u2010pharmacological strategies, including dietary restriction (DR). DR refers to a nutritional paradigm aimed at promoting overall health by modifying the balance between energy consumption and expenditure. Studies have demonstrated that DR effectively extends the healthy lifespan, delays the aging process, and achieves promising results in the prevention and treatment of AD in preclinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this review we collected related studies and viewpoints by searching on PubMed database using the keywords. Most of the citations were published between 2015 and 2025. A few older literatures were also included due to their relevance and significance in this field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We first provide a concise overview of the current therapeutic and preventive strategies for AD. Then, we introduce several specific DR protocols and their favorable effects on AD. Furthermore, the potential mechanisms underlying the benefits of DR on AD are discussed. Finally, we briefly highlight the role of DR in maintaining brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review may offer valuable insights into the development of innovative non\u2010pharmacological strategies for AD treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70392","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T14:02:23Z","timestamp":1744898543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations"],"prefix":"10.1111","volume":"31","author":[{"given":"Zijiao","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated Hospital, Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated Hospital, Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Psychiatry Dalian Seventh People's Hospital  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated Hospital, Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-2705","authenticated-orcid":false,"given":"Weidong","family":"Le","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research Shanghai University of Medicine and Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cDementia 2023.\u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dementia."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094962"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102955"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117172"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12683"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.12.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107861"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001104\u2010w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010021\u201000411\u20104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.004"},{"key":"e_1_2_10_13_1","volume-title":"The Rate of Living","author":"Pearl R.","year":"1928"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100244\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23041989"},{"key":"e_1_2_10_17_1","volume-title":"Global Status Report on the Public Health Response to Dementia","author":"World Health Organization","year":"2021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20102667(21)00249\u20108"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010220724"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwae026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.20517\/and.2023.16"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12465"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2020"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/22124"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.Wnl.0000148604.77591.67"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.023"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102192"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102348"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201001053\u20108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010023\u201000883\u20102"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj5958"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12258"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2015.1220"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2014.1126"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.02.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20100908\u20100"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010160867"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010151106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.20517\/and.2022.37"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.9.1027"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102463"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004183\u2010x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1147684"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010023\u201001145\u20103"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.01.004"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214564"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2024.0171"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013069.pub2"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)01296\u20100"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110835"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.02.009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010024\u201001166\u20104"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.033"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2739"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci46229"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000466\u20109"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010015\u20100408\u20106"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1306"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173635"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv057"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.06.001"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.10.043"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.03.028"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo02611h"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010231117"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.12.011"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234915"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12999"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695810"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010020\u20100342\u2010y"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020316"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.04.015"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00395"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.019"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.014"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000831\u2010w"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20639"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001903.pub5"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x20666220830102628"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201005860\u2010z"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010141074"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20062"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14368"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000783\u2010x"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9874159"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.04.011"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.11.009"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000207176"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201054187\u2010x"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14823"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009897\u20101"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104745"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15105"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114920"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.11.023"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13958"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(20)30231\u20103"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010020\u201000796\u20104"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010016\u20100674\u20100"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13706"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2017.1337707"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101999"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.09.014"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001552\u2010y"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1334461"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030464"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.03.004"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/77046"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20102094\u201011\u201085"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010023\u201001158\u20100"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.18.3288"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102355"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003934\u20100"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010013\u20101423\u2010y"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/238463"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.037"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000649\u20100"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201013601\u2010y"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010022\u201000311\u2010y"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00017\u201008"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2323752"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.121"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172156"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.6.46"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.332126"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201044343\u20103"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101636"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.012"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001102\u20104"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.09.023"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202357269"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302368"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.04.025"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14062"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12421"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac001"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153332"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1092852918001566"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092644"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.70006"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12206"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20110320"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797397"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.70392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:05:09Z","timestamp":1773068709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":146,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cns.70392"],"URL":"https:\/\/doi.org\/10.1111\/cns.70392","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70392"}}