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Pathologically, the loss of dopaminergic (DA) neurons triggered by the deposition of \u03b1\u2010synuclein (SNCA) leads to the decrease in dopamine levels affecting motor and cognitive functions of the brain. Current pharmacotherapy for PD only addresses its symptoms but is not able to halt its progression. Traditional medicines are being increasingly used for the treatment of neurodegenerative disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study investigated the effects of Neurogrit Gold (NG), a herbo\u2010mineral prescription medicine, on a Parkinson's model of <jats:styled-content style=\"fixed-case\"><jats:italic>Caenorhabditis elegans<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chemical characterization of NG was performed on HPLC and GC\u2013MS\/MS platforms. Evaluation of NG was done in the neurotoxicant 6\u2010OHDA\u2010induced N2, BZ555, and NL5901 strains of <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u2009elegans<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was observed that NG treatment did not hamper the lifespan, survival, and progeny development of <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u2009elegans<\/jats:italic><\/jats:styled-content> strains. The worms treated with NG were able to resist the deleterious effects of 6\u2010OHDA on survival, progeny development, body bends, and chemotaxis in N2 and DA neuron degeneration in BZ555 worms. In NL5901 worms, NG treatment reduced SNCA aggregation, restored lipid content, as well as improved body bends, chemotaxis, and food uptake. Gene expression studies on 6\u2010OHDA exposed and NG\u2010treated N2 worms suggest that the neuroprotective effects of NG stem from its ability to regulate genes involved in mitochondrial autophagy (<jats:italic>pink\u20101<\/jats:italic>, <jats:italic>pdr\u20101<\/jats:italic>); dopamine synthesis (<jats:italic>cat\u20102<\/jats:italic>); redox (<jats:italic>sod\u20103<\/jats:italic>) and protein folding homeostasis (<jats:italic>hsf\u20101<\/jats:italic>, <jats:italic>hsp\u201012.3<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neurogrit Gold has robust neuroprotective effects, making it a suitable treatment option against etiologies of Parkinson's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70401","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:14:46Z","timestamp":1746684886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurogrit Gold Attenuates 6\u2010<scp>OHDA<\/scp>\u2010Induced Dopaminergic Neurodegeneration in Parkinson's Model of <i>Caenorhabditis elegans<\/i> by Reducing \u03b1\u2010Synuclein Accumulation and <i>Pink\/Pdr\u20101<\/i> Driven Mitochondrial Dysfunction"],"prefix":"10.1111","volume":"31","author":[{"given":"Acharya","family":"Balkrishna","sequence":"first","affiliation":[{"name":"Drug Discovery and Development Division Patanjali Research Foundation  Haridwar India"},{"name":"Department of Allied and Applied Sciences University of Patanjali  Haridwar India"},{"name":"Patanjali Yog Peeth (UK) Trust  Glasgow 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