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Despite\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      's established role in predicting cardiovascular outcomes, its impact on stroke risk and prognosis has not been fully explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 462,550 participants from the\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      Biobank with\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      assessments, and participants were stratified into three categories based on tertiles of\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      . The primary outcomes were stroke and its subtypes (ischemic and hemorrhagic stroke). Cox proportional hazard models and restricted cubic spline regression were used to analyze associations between\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      and outcomes. Secondary analyses investigated poststroke adverse events (depression, disability, epilepsy, and delirium). Mediation analyses were conducted to explore the underlying mechanisms driven by inflammatory markers,\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      , and stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 13.9\u2009years, 12,325 stroke cases were recorded. Compared to the lowest\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      tertile (&lt;\u20096.525\u2009mg\/kg\/min), individuals in the highest tertile (&gt;\u20098.494\u2009mg\/kg\/min) demonstrated a significantly reduced risk of stroke (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20090.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.50\u20130.56), particularly ischemic stroke (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20090.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.50\u20130.57). Higher\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      levels were also associated with a decreased risk of poststroke adverse outcomes (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u2009=\u20090.83, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.73\u20130.94), with similar risk estimates observed for depression, disability, epilepsy, and delirium. Furthermore, inflammatory markers partially mediated the relationship between\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      and stroke risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Elevated\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      levels were associated with decreased risks of stroke and poststroke adverse outcomes. These findings suggest improving insulin sensitivity, as reflected by higher\n                      <jats:styled-content style=\"fixed-case\">eGDR<\/jats:styled-content>\n                      , maybe a potential therapeutic target for stroke prevention or stroke rehabilitation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70420","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:01:01Z","timestamp":1749726061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations of Estimated Glucose Disposal Rate With Stroke Risk and Poststroke Adverse Outcomes: A Prospective Cohort Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Xiaxuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Jinan University  Guangzhou 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