{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:11:31Z","timestamp":1792181491970,"version":"4.4.0"},"reference-count":188,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960221"],"award-info":[{"award-number":["81960221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260249"],"award-info":[{"award-number":["82260249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dysfunction of the blood\u2013brain barrier (BBB) is an important pathological mechanism in central nervous system (CNS) diseases and can trigger a series of pathological reactions, such as neuroinflammatory responses, oxidative stress, immune infiltration, etc., thereby worsening brain damage. However, pericytes are often overlooked by researchers, and no review research has yet summarized the mechanism by which pericytes contribute to BBB dysfunction in CNS diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Therefore, this review explores the pathophysiology of BBB dysfunction in CNS diseases and provides a detailed account of the biological characteristics of pericytes, especially the controversy over their biomarkers. Subsequently, we review the role of pericytes in CNS diseases such as Alzheimer's disease, vascular dementia, multiple sclerosis, ischemic stroke, and hemorrhagic stroke, with a particular focus on the role of pericytes in BBB dysfunction. In addition, we also discuss treatments based on pericytes, such as regenerative medicine that induces pericyte differentiation and Pericyte\u2010Extracellular Vesicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review aims to provide a more comprehensive understanding and guidance on the role of pericytes in BBB dysfunction in CNS diseases and serve clinical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70422","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:20:12Z","timestamp":1747286412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Blood\u2013Brain Barrier (<scp>BBB<\/scp>) Dysfunction in <scp>CNS<\/scp> Diseases: Paying Attention to Pericytes"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8612-989X","authenticated-orcid":false,"given":"Tianrui","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Clinical Medicine Jiujiang University  Jiujiang China"},{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4940-8557","authenticated-orcid":false,"given":"Zixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Clinical Medicine Jiujiang University  Jiujiang China"},{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Clinical Medicine Jiujiang University  Jiujiang China"},{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"},{"name":"Department of Medical Laboratory Affiliated Hospital of Jiujiang University  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Clinical Medicine Jiujiang University  Jiujiang China"},{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Clinical Medicine Jiujiang University  Jiujiang China"},{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang China"},{"name":"Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences Jiujiang University  Jiujiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2017"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15610340"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317473"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193108"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3265"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111779"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12250"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.10.001"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14853"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.11.013"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12782"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104986"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910625"},{"key":"e_1_2_16_17_1","first-page":"559","article-title":"Note Sur le Developpement de la Tunique Contractile Des Vaisseaux","volume":"59","author":"Rouget C.","year":"1874","journal-title":"Comptes Rendus de l'Acad\u00e9mie des Sciences"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02593544"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4489"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.132654"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2946"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.01.005"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.019"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20108166(86)90026\u20101"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2014.06.004"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-031522-034807"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.026"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8008"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48134-2"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjtee.2020.02.006"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00349.2016"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.2.4.041402"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83532"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00171.2013"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318\u2010024\u201000349\u20101"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176225"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.1.147"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1200"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071746"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2315"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1294-0"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63868-0"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-006-9061-x"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00893-5"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00902-0"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.97165"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abl5405"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-32"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62062375.x"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.6.JNS17860"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04167-7"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710848114"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0727-24.2024"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09513"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109890"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17697340"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13324"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0123-z"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0484-5"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.07.027"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00136.2018"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21817"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02215-w"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-28"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600570"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05193"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.001"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011321108"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13165"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1936192100"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.10.014"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00108"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00793-2"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154118"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01753-w"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25024"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26232"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2022"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.601324"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.183061"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.143131"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.317324"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331694"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000182903.16652.d7"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.11.023"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46322"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.11.108"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00380.x"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5322.55"},{"key":"e_1_2_16_90_1","first-page":"633","article-title":"Pericyte Morphology and Function","volume":"36","author":"Alarcon\u2010Martinez L.","year":"2021","journal-title":"Histology and Histopathology"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.01.016"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2477"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.521161"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188222"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2889"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111622"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045499"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.06.052"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.04.023"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10357"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-139"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00741-8"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0097"},{"issue":"1","key":"e_1_2_16_104_1","first-page":"S87","article-title":"Neurovascular Defects and Faulty Amyloid\u2010\u03b2 Vascular Clearance in Alzheimer's Disease","volume":"33","author":"Sagare A. P.","year":"2013","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12004"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11087"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0286-0"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010020\u201002134\u2010w"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.05.028"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-106"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-018-9620-9"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00726.2020"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221111598"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0028"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0385-6"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111416"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092314"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2891\u201016.2016"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172755"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15621499"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.12.003"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.03.026"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12935"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00693782"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124231"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0650-x"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24548"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10498"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu046"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101248"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800069-JLR200"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.102277"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400024q"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.12.030"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102278"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.032"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00056"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600375"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221146401"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17743670"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-021-00255-2"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.01.006"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00095-9"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00801-6"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11312"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02358-x"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113081"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701252104"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00781.x"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601378"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1563-z"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E4"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.036946"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-021-09796-4"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15606456"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.1.121"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600214"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010014\u20101295\u2010x"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0523-9"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319288"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103880"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42370-z"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1996.0049"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3475"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0168-3"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0084"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.07.007"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.12.006"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1977"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050214-013407"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1201-5"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48562"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43169"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2641-7"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689721993774"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00795-y"},{"key":"e_1_2_16_177_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17719645"},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.178"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00319"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-019-02788-x"},{"key":"e_1_2_16_181_1","first-page":"4167","article-title":"Exosomes Containing miR\u2010122\u20105p Secreted by LPS\u2010Induced Neutrophils Regulate the Apoptosis and Permeability of Brain Microvascular Endothelial Cells by Targeting OCLN","volume":"13","author":"Li Q.","year":"2021","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00828-0"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02282-0"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-017-0090-x"},{"key":"e_1_2_16_185_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201020\u20101727"},{"key":"e_1_2_16_186_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0964OC"},{"key":"e_1_2_16_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-022-00223-9"},{"key":"e_1_2_16_188_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm6543"},{"key":"e_1_2_16_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19042-y"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T09:19:33Z","timestamp":1752743973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":188,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/cns.70422"],"URL":"https:\/\/doi.org\/10.1111\/cns.70422","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70422"}}