{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:02:35Z","timestamp":1788444155337,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203170"],"award-info":[{"award-number":["82203170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001777"],"award-info":[{"award-number":["82001777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202021"],"award-info":[{"award-number":["7202021"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Supplementary motor area (SMA) syndrome is a common complication after SMA glioma resection. The compensatory mechanism of the structural sensorimotor network (SMN) and the factors influencing the recovery time of SMA syndrome have not been investigated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Pre\u2010 and postoperative diffusion tensor images of 42 low\u2010grade glioma patients with SMA syndrome were processed to construct white matter connectomes. Patients were classified into fast and slow\u2010recovery groups according to whether postoperative motor disorder recovers within 7\u2009days. Fiber counts between nodes and graph theory topological properties were calculated. The shortest distance from the surgical region to the corticospinal tract (\n d<\/jats:italic>\n CST<\/jats:sub>\n ) and the upper limb region of Brodmann area 4 (A4ul) was measured to find correlations with recovery time. Cox regressions were conducted to identify factors associated with SMA syndrome recovery time. A general linear model was formed using significant factors in multivariate Cox analysis to predict recovery time.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Decrease of fiber number between lesioned\u2010hemispheric A4ul and contralateral SMN is correlated with prolongation of recovery time. Compared with the slow\u2010recovery group, a higher increase of nodal degree centrality and nodal efficiency of ipsilateral A4ul was found in the fast\u2010recovery group (nodal efficiency: left pre\u2010op: 0.182\u2009\u00b1\u20090.009, left post\u2010op: 0.231\u2009\u00b1\u20090.008,\n p<\/jats:italic>\n \u2009<\u20090.0001; right pre\u2010op: 0.157\u2009\u00b1\u20090.021, right post\u2010op: 0.195\u2009\u00b1\u20090.018,\n p<\/jats:italic>\n \u2009=\u20090.0011); (nodal degree centrality: left pre\u2010op: 1.985\u2009\u00b1\u20090.166; left post\u2010op: 3.195\u2009\u00b1\u20090.230,\n p<\/jats:italic>\n \u2009<\u20090.0001; right pre\u2010op: 1.620\u2009\u00b1\u20090.389; right post\u2010op: 2.411\u2009\u00b1\u20090.452,\n p<\/jats:italic>\n \u2009=\u20090.0005). Multivariate Cox analysis indicated that the increase in nodal efficiency of A4ul and\n d<\/jats:italic>\n CST<\/jats:sub>\n were protective factors for SMA syndrome recovery time. A significant negative correlation between the predict score and recovery time was found in the left lesion group (\n r<\/jats:italic>\n \u2009=\u2009\u22120.756,\n p<\/jats:italic>\n \u2009<\u20090.0001), and the same trend was found in the right lesion group (\n r<\/jats:italic>\n \u2009=\u2009\u22120.531,\n p<\/jats:italic>\n \u2009=\u20090.076).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study revealed an increase in lesioned\u2010hemispheric A4ul nodal efficiency and long\n d<\/jats:italic>\n CST<\/jats:sub>\n as protective factors in SMA syndrome recovery. A decrease in the number of interhemispheric fibers connecting lesioned\u2010hemispheric A4ul to nodes on the contralateral hemisphere was correlated with the long recovery time of SMA syndrome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cns.70426","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:21:42Z","timestamp":1746850902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Variation of White Matter Connectome After Surgery Revealed Factors Affecting Supplementary Syndrome Recovery Time in Low\u2010Grade Glioma Patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Shengyu","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing 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Institute Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Fan","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-7992","authenticated-orcid":false,"given":"Wenbin","family":"Ma","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical 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