{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:03:24Z","timestamp":1791482604793,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100907"],"award-info":[{"award-number":["32100907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Ferroptosis plays a critical role in stroke pathophysiology, yet its dynamics during recovery remain unclear. This study aimed to investigate the evolution of ferroptosis throughout post\u2010stroke recovery and evaluate auricular transcutaneous vagus nerve stimulation (atVNS) as a therapeutic intervention, focusing on the involvement of \u03b17 nicotinic acetylcholine receptor (\u03b17nAChR)\u2010mediated mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a middle cerebral artery occlusion (MCAO) mouse model, we examined ferroptosis\u2010related protein expression (GPX4, ACSL4, TfR) and iron levels across acute to chronic recovery phases. The therapeutic effects of atVNS were evaluated through the assessment of ferroptosis markers, neurogenesis, angiogenesis, cognitive function, and neuroinflammation. \u03b17nAChR knockout mice were used to investigate the receptor's role in atVNS\u2010mediated recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed sustained alterations in ferroptosis markers and iron levels throughout post\u2010stroke recovery. atVNS treatment reduced ferroptosis progression by modulating GPX4 and ACSL4 expression, enhanced neurogenesis and angiogenesis, improved cognitive recovery, and reduced neuroinflammation. These beneficial effects were absent in \u03b17nAChR knockout mice, while atVNS increased neuronal \u03b17nAChR expression in wild\u2010type mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study reveals the persistent involvement of ferroptosis in stroke recovery and demonstrates that atVNS provides comprehensive neuroprotection through \u03b17nAChR\u2010dependent mechanisms. These findings establish atVNS as a promising noninvasive therapeutic approach for stroke recovery and highlight \u03b17nAChR signaling as a potential therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70439","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:37:37Z","timestamp":1747373857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Auricular Transcutaneous Vagus Nerve Stimulation Enhances Post\u2010Stroke Neurological and Cognitive Recovery in Mice by Suppressing Ferroptosis Through \u03b17 Nicotinic Acetylcholine Receptor Activation"],"prefix":"10.1111","volume":"31","author":[{"given":"Hongyan","family":"Gong","sequence":"first","affiliation":[{"name":"MOE Key Laboratory for Neuroinformation, School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Anesthesiology, Qingdao 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