{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:19:34Z","timestamp":1788283174832,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extended interval dosing (EID) of natalizumab (NTZ) every 6\u2009weeks may reduce adverse events while maintaining efficacy. This study compared the effectiveness and safety of EID versus standard interval dosing (SID) in relapsing\u2013remitting multiple sclerosis (RRMS) patients, focusing on treatment adherence and its impact on clinical and radiological outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved 80 patients with RRMS from seven clinics: 52 received SID (300\u2009mg every 4\u2009weeks), and 28 received EID (300\u2009mg every 6\u2009weeks). Clinical and radiological disease activity, treatment adherence, and adverse events were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SID and EID groups differed significantly in sex distribution (78.8% female in SID vs. 46.4% in EID, <jats:italic>p<\/jats:italic>\u2009=\u20090.007), but median age was similar (32 vs. 36\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.209). Clinical and radiological worsening rates were similar between the groups, with no significant differences (combined worsening: 9.6% in the SID group vs. 17.9% in the EID group, <jats:italic>p<\/jats:italic>\u2009=\u20090.308; radiological worsening: 5.8% in the SID group vs. 7.1% in the EID group, <jats:italic>p<\/jats:italic>\u2009=\u20091.00; clinical worsening: 9.6% in the SID group vs. 10.7% in the EID group, <jats:italic>p<\/jats:italic>\u2009=\u20091.00). Adherence rates were comparable across both dosing regimens, and no significant differences were observed in terms of treatment discontinuation. No progressive multifocal leukoencephalopathy cases were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both SID and EID provide comparable efficacy and safety profiles, with similar adherence rates. Despite the observed sex distribution imbalance, additional analyses confirmed no significant sex\u2010 or group\u2010related differences in baseline disability or clinical worsening, strengthening the interpretation that EID preserves efficacy. Findings should still be interpreted with caution due to the study's retrospective nature and limited sample size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70445","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:41:41Z","timestamp":1747647701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Efficacy and Safety of Extended Versus Standard Interval Dosing of Natalizumab in Relapsing\u2013Remitting Multiple Sclerosis Patients: A Multicenter Analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Meral","family":"Sefero\u011flu","sequence":"first","affiliation":[{"name":"Department of Neurology University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-5285","authenticated-orcid":false,"given":"Abdulkadir","family":"Tun\u00e7","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali \u00d6zhan","family":"S\u0131vac\u0131","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge Piri","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Samsun University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena Destan","family":"B\u00fcn\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Ethemo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Harran University  Urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclgen Yalaz","family":"Tekan","sequence":"additional","affiliation":[{"name":"Clinic of Neurology \u015ei\u015fli Hamidiye Etfal Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Fatih","family":"Yetkin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527\u20103458.2007.00003.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020696"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044396"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051782"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70040\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30282-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312940"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285614540224"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010019\u201000776\u20107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.06.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.190"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30470\u20102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010020\u201000187\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010024\u201012273\u20109"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00351"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-024-02480-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00143\u20100"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.123102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053297"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052\u2010200206000\u201000003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11101006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122686"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010020\u201000212\u20105"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30151\u20106"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T09:19:19Z","timestamp":1752743959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/cns.70445"],"URL":"https:\/\/doi.org\/10.1111\/cns.70445","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70445"}}