{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:06:36Z","timestamp":1773731196450,"version":"3.50.1"},"reference-count":181,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR069292"],"award-info":[{"award-number":["RS\u20102022\u2010NR069292"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Head and neck cancer (HNC) encompasses a heterogeneous group of malignancies originating in the oral cavity, pharynx, nasopharynx, larynx, paranasal sinuses, and salivary glands. Accumulating evidence indicates that metabolic syndrome (MetS) characterized by a constellation of conditions including central adiposity, hyperglycemia, dyslipidemia, hypertension, and insulin resistance, may significantly influence cancer pathogenesis and progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MetS has been epidemiologically linked to elevated risk for multiple malignancies through various metabolic mechanisms involving chronic systemic inflammation, insulin resistance, and dysregulated lipid metabolism. Especially in HNC, recent studies demonstrated that MetS and metabolic imbalance conditions may contribute to carcinogenesis, disease progression, and clinical outcomes, but the exact mechanisms behind the association between excess fat accumulation and HNC risk remain unclear. Considering previous studies, pharmacological agents targeting metabolic pathways, including biguanides (metformin), thiazolidinediones, sodium\u2010glucose cotransporter\u20102 (SGLT\u20102) inhibitors, and HMG\u2010CoA reductase inhibitors (statins) are being investigated for potential repurposing in cancer prevention and adjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Here, we summarize the latest evidence on the relationship between MetS and HNC, highlighting the therapeutic potential of anti\u2010diabetes drugs and anti\u2010dyslipidemia drugs in ameliorating various pathological problems in HNC patients with MetS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70446","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:38:33Z","timestamp":1747647513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Potential of Anti\u2010Diabetes Drugs and Anti\u2010Dyslipidemia Drugs to Mitigate Head and Neck Cancer Risk in Metabolic Syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Sujung","family":"Yeom","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Chonnam National University Medical School &amp; Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Chonnam National University Medical School &amp; Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-8507","authenticated-orcid":false,"given":"Juhyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anatomy Chonnam National University Medical School  Hwasun Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-023-01634-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01550-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci11020042"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17122.1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0336"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051090"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S283840"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24397"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-022-00599-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.492"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq006"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7180\/kmj.24.108"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S392051"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24687"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1003"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-021-00261-w"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133277"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02202-5"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14192132"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(05)74065-3"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.58676\/sjmas.v1i2.12"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1371"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21866"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33172"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.070"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx012"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-058392"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020485"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.247"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920206779315737"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.05.042"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.8.4499"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4972"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1009"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-019-0358-9"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20472"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0749"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00596"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0930"},{"issue":"3","key":"e_1_2_12_47_1","first-page":"S596","article-title":"Leptin and Cancer: Pathogenesis and Modulation","volume":"16","author":"Dutta D.","year":"2012","journal-title":"Indian Journal of Endocrinology and Metabolism"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.04.014"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-021-00569-w"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21911"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.01053.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0655"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-8-74"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051578"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302010000700002"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3075"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-06-0027"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2011.1388"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2003.12.003"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00091.2007"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.236"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007439200"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.229"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29126"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25301"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1975"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15174250"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112729"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3067-1"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5479"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945010792006799"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304984200"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2166-6643"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101624\u20102897"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0087"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)34572-2"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.5.330"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06\u20100922"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20166"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091402"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079708"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0350-5"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.6000\/1929-2279.2018.07.03.1"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.3109S"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.21305"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051090"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0065"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.803473"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477890"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u2010511X\u201013\u201016"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101230"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/4015167"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30229"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000770"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000578"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44877"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13493"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01049-5"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23192"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0283"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.07802"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13236062"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.03.008"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.2306\/scienceasia1513-1874.2024.078"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15164118"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37061-0"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116687"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043283"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.82674"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp380"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2013.11.004"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.20513"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114524001880"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.019"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.35607"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813450801954451"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2390-3"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-33"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0263"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5526"},{"issue":"9","key":"e_1_2_12_122_1","first-page":"4885","article-title":"Mechanisms of Metformin Inhibiting Cancer Invasion and Migration","volume":"12","author":"Chen Y. C.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0184-9"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw410"},{"issue":"6","key":"e_1_2_12_125_1","first-page":"57","article-title":"Metformin in Cancer Prevention and Therapy","volume":"2","author":"Kasznicki J.","year":"2014","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.07.007"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00701-5"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00990-3"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12172182"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/928127"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2994"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00362"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx106"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0033-2"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.028"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1716779"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.115"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061537"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2466"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.178"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2229"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23743"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12820"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463\u2010019\u20100348\u20105"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0426"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106536"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050982"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00436"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118742106276363231123071425"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002773"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.850750"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1628"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3525"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21283"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1177\/2057178X17739809"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/845340"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26046"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.020"},{"key":"e_1_2_12_160_1","doi-asserted-by":"crossref","unstructured":"L.Li O. H. I.Chou K. K.Mak et\u00a0al. \u201cNasopharyngeal Carcinoma and Head and Neck Cancer in Patients With Type\u20102 Diabetes Mellitus Receiving SGLT2I DPP4I or GLP1a: A Population\u2010Based Cohort Study \u201d2024.","DOI":"10.2139\/ssrn.4703774"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02925-y"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2024.2343338"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-09020-1"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041001"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15819"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0310-9"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-22"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.2.7584"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20144212"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.08.008"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.766560"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3180"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106039"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ19-0428"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02177-2"},{"issue":"7","key":"e_1_2_12_176_1","article-title":"SGLT2 Inhibitors as Potential Anticancer Agents","volume":"11","author":"Basak D.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.12.010"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1751"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.11.008"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02041-2"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.04.011"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.2078"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T09:19:24Z","timestamp":1752743964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":181,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/cns.70446"],"URL":"https:\/\/doi.org\/10.1111\/cns.70446","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70446"}}