{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:09:09Z","timestamp":1786241349988,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171192"],"award-info":[{"award-number":["82171192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Aging is associated with increased responsiveness to anesthesia\u2010induced burst suppression, which correlates with postoperative cognitive dysfunction and delirium. This study aims to investigate whether the enhanced burst suppression in aged mice under anesthesia is associated with a reduction in ATP levels within the medial prefrontal cortex (mPFC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EEG recordings were conducted to analyze the burst suppression, and in\u00a0vivo fiber\u2010optic recording techniques were employed to monitor fluctuations in ATP levels within the mPFC during sevoflurane anesthesia. To elucidate the underlying mechanisms contributing to the observed variations in ATP levels in aged mice, mRNA sequencing was performed. Furthermore, site\u2010specific viral knockdown strategies were implemented to validate the mechanisms of action of key molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that sevoflurane anesthesia resulted in an increased burst suppression ratio, extended EEG suppression time, and reduced ATP levels in aged mice. Administration of ATP mitigated the anesthesia\u2010induced increase in EEG suppression time. RNA sequencing revealed that NDUFA10, an energy metabolism\u2010related gene, was down\u2010regulated in aged mice. Knockdown of NDUFA10 in mPFC increased burst suppression, whereas the administration of ATP attenuated these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NDUFA10\u2010driven ATP depletion in the mPFC prolongs sevoflurane\u2010induced burst suppression in aged mice, implicating energy metabolism regulation as a strategy to optimize geriatric anesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70453","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:45:07Z","timestamp":1748227507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>NDUFA10<\/scp>\u2010Mediated <scp>ATP<\/scp> Reduction in Medial Prefrontal Cortex Exacerbates Burst Suppression in Aged Mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Huiwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated 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