{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:59:39Z","timestamp":1778216379115,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030037"],"award-info":[{"award-number":["82030037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z221100002722007"],"award-info":[{"award-number":["Z221100002722007"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z221100007422016"],"award-info":[{"award-number":["Z221100007422016"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The high risk of resection surgery for hypothalamic hamartoma (HH) epilepsy drives interest in minimally invasive treatment. Stereo\u2010electroencephalography\u2010guided three\u2010dimensional radiofrequency thermocoagulation (SEEG\u20103D RFTC) offers an alternative option. We investigated this technology's efficacy, safety, and prognostic risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HH who underwent SEEG\u20103D RFTC were retrospectively analyzed. A high\u2010density focal stereo\u2010array electrode implantation was adopted. SEEG\u20103D RFTC was performed between two contiguous contacts of the same electrode or adjacent contacts of different electrodes. Outcomes were separately evaluated for clinical seizures, gelastic seizures (GS), and non\u2010gelastic seizures (nGS). Kaplan\u2013Meier survival analysis was used to assess treatment effectiveness. Risk factors were analyzed using log\u2010rank tests and Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients were enrolled. The mean follow\u2010up was 41.00\u2009\u00b1\u200918.19\u2009months. Seizure freedom was obtained by 48\/69 (69.57%) patients for clinical seizures, 50\/62 (80.65%) patients for GS, and 41\/54 (75.93%) patients for nGS. Surgical procedures were well tolerated. In this study, the proportion of patients experiencing long\u2010term complications was 10.14%. The percentages of HH ablation (<jats:italic>p<\/jats:italic>\u2009=\u20090.003; hazard ratio 0.956, 95% confidence interval 0.928\u20130.985) and HH attachment ablation (<jats:italic>p<\/jats:italic>\u2009=\u20090.001; hazard ratio 0.931, 95% confidence interval 0.892\u20130.970) were significantly associated with seizure outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optimized SEEG\u20103D RFTC is an effective and safe option for HH\u2010related epilepsy and is especially suitable for use where laser interstitial thermal therapy is unavailable. Complete ablation of the HH and attachment site is essential for good outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70462","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:01:01Z","timestamp":1749726061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimized Stereo\u2010Electroencephalography\u2010Guided Three\u2010Dimensional Radiofrequency Thermocoagulation for Hypothalamic Hamartomas\u2010Related Epilepsy: A Single\u2010Center Experience in 69 Patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Yang","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Clinical Research Center for Epilepsy Capital Medical University  Beijing China"},{"name":"Department of Clinical &amp; 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