{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:11:13Z","timestamp":1788487873361,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Argatroban is widely used for patients with acute branch atheromatous disease (BAD)\u2010related stroke, but its efficacy remains unclear. This study aims to evaluate its clinical outcomes in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, MRI\u2010based cohort (BAD\u2010study) was conducted across 20 hospitals in China from June 2021 to June 2023, enrolling patients aged 18\u201380\u2009years with BAD\u2010related stroke within 72\u2009h of onset. Patients were divided into two groups: Argatroban and non\u2010argatroban. The primary outcome was an excellent outcome, defined as a modified Rankin Scale (mRS) score of 0\u20131 at 90\u2009days. Secondary outcomes included good outcome (mRS 0\u20132), mRS score, Barthel Index score at 90\u2009days, and NIHSS score at 7\u2009days. Logistic regression analyses were performed to assess the association between argatroban and outcomes after propensity score matching (PSM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 467 patients were included, with a median age of 60\u2009years and a median NIHSS score of 4 at admission. Eighty\u2010six patients (18.4%) were in the argatroban group, and 381 patients (81.6%) were in the non\u2010argatroban group. After PSM, excellent outcomes occurred in 60.0% of the argatroban group and 64.2% of the non\u2010argatroban group (odds ratio [OR] =\u20090.84, 95% CI: 0.47\u20131.49, <jats:italic>p<\/jats:italic>\u2009=\u20090.542). Argatroban was not significantly associated with secondary outcomes and remained ineffective in sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Argatroban was not associated with excellent outcome at 90\u2009days in patients with acute BAD\u2010related stroke. Our study suggests that the risks and benefits of argatroban need reevaluation in patients with BAD\u2010related stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70467","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:35:32Z","timestamp":1750214132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association Between Argatroban and Outcomes of Branch Atheromatous Disease: A Propensity\u2010Matched Analysis From <scp>MRI<\/scp>\u2010Based Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-9564","authenticated-orcid":false,"given":"Shengde","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-743X","authenticated-orcid":false,"given":"Guofang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuzhou Central Hospital  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of North China University of Science and Technology  Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7877-612X","authenticated-orcid":false,"given":"Jun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"BAD\u2010study 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