{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:08:28Z","timestamp":1792807708769,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171885"],"award-info":[{"award-number":["82171885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302142"],"award-info":[{"award-number":["82302142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between white matter integrity changes and attention\/executive function in cerebral small vessel disease (CSVD), focusing on tract\u2010specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW\u2010corrected fractional anisotropy (FAt) and FW\u2010corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal\u2010appearing white matter (NAWM). WMH volume, gray\/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging\u2010cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM\/WMH FAt positively associated with attention\/executive function, whereas NAWM\/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NAWM FAt significantly impacts attention\/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70475","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:01:01Z","timestamp":1749726061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Free Water\u2010Corrected Fractional Anisotropy in Normal\u2010Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4004-9565","authenticated-orcid":false,"given":"Qingyang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-9434","authenticated-orcid":false,"given":"Yage","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-7467","authenticated-orcid":false,"given":"Wentao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Renji\u2010UNSW CHeBA Neurocognitive Center, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Health Manage Center, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12221"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2307"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab076"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1096808"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1019088"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1045910"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.043"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01638-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28092"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70060-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201134"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.998051"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120790"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23350"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209306"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241305480"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2024.103706"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8591"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26722"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-019-02017-1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4830"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16635657"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103154"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207514"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00217"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.865307"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12073"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.6.4.358"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000034"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3383"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3501"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14072"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10994-013-5337-8"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2024"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab003"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13830"},{"key":"e_1_2_11_41_1","first-page":"2575","article-title":"Cardiovascular Comorbidities, Inflammation, and Cerebral Small Vessel Disease","volume":"117","author":"Evans L. E.","year":"2021","journal-title":"Cardiovascular Research"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011783"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70094"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.05.012"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy338"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26758"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1074730"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119303"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16651268"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005684"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020980"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13816"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102630"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121010"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02376-2"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad308"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.035"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:30:55Z","timestamp":1754904655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/cns.70475"],"URL":"https:\/\/doi.org\/10.1111\/cns.70475","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70475"}}