{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:21:49Z","timestamp":1792480909406,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024ZYD0272"],"award-info":[{"award-number":["2024ZYD0272"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty\u2010seven ACMP patients and 29 age\u2010 and sex\u2010matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3\u2009days post\u2010exposure. Cognitive functions were assessed using the mini\u2010mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After follow\u2010up, 27.66% (13\/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%,\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u2009\u22122.225,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) compared to the Recovery group. The cognitive function scores, delayed memory\u2010related sub\u2010items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve\u2009=\u20090.887,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090001). Correlation analysis showed that MoCA\u2010delayed recall was positively associated with the volume of the left CA1 subfield (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.357,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020), and MMSE\u2010delayed recall was positively associated with the volume of the left presubiculum (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.323,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non\u2010invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70482","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:55:08Z","timestamp":1750658108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning"],"prefix":"10.1111","volume":"31","author":[{"given":"Mengyue","family":"Tang","sequence":"first","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Deng","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ji","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Huang","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3852-5742","authenticated-orcid":false,"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging, Department of Radiology  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2012.300674"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102598"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/526483"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990599121601"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6584"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406105200"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0241-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0067-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2530253"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.067"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1867"},{"key":"e_1_2_9_13_1","first-page":"31","volume-title":"The Central Nervous System and Carbon Monoxide Poisoning. 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