{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:11:05Z","timestamp":1792019465968,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371382"],"award-info":[{"award-number":["82371382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085MH256"],"award-info":[{"award-number":["2308085MH256"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigates the link between ubiquitin\u2010specific peptidase 9 X\u2010linked (USP9X) and Alzheimer's disease (AD) pathogenesis, aiming to identify potential targets for AD diagnosis, treatment, and drug development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We constructed a USP9X\u2010inhibited expression mouse model and assessed cognitive and memory functions. We also measured Tau phosphorylation and APP levels in the hippocampal dentate gyrus (DG) and analyzed neuronal functions, dendritic spine features, late apoptosis, and autophagy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice with USP9Xinhibition exhibited impaired cognitive and memory functions. An increase in the APP levels and Tau hyperphosphorylation in the DG resembled AD\u2010like pathology. Neurons exhibited abnormal functions, altered dendritic spine morphology, increase in neuronal apoptosis, and dysfunctions, similar to neuron loss observed in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Investigating the role of USP9X in AD could provide valuable insights for developing novel diagnostic and therapeutic strategies for AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70493","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T11:53:22Z","timestamp":1752407602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Downregulation of <scp>USP9X<\/scp> in the <scp>DG<\/scp> Region of the Hippocampus Leads to <scp>AD<\/scp>\u2010Like Cognitive Dysfunction in Mice"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1478-8592","authenticated-orcid":false,"given":"Xiaochuan","family":"Qi","sequence":"first","affiliation":[{"name":"Anhui Engineering Research Centre for Neural Regeneration Technology and Medical New Materials Bengbu Medical University  Bengbu China"},{"name":"School of Laboratory Medicine Bengbu Medical University  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0914-9193","authenticated-orcid":false,"given":"Mengjiao","family":"Ying","sequence":"additional","affiliation":[{"name":"Anhui Engineering Research Centre for Neural Regeneration Technology and Medical New Materials Bengbu Medical University  Bengbu China"},{"name":"School of Life Sciences Bengbu Medical University  Bengbu 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