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Their blood and cerebrospinal fluids were harvested for analysis of inflammatory and neuronal injury indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 67 patients were included in this study: 32 had stent placement under general anesthesia and 35 had open surgery to repair the aneurysm. No patients in the stent placement group had POD, but 9 patients in the open surgery group had POD (25.7%). Patients with POD had a lower body temperature at the end of surgery than patients without POD [36.3\u00b0C (35.7\u00b0C\u201336.6\u00b0C) vs. 36.7\u00b0C (36.3\u00b0C\u201337.0\u00b0C), <jats:italic>p<\/jats:italic>\u2009=\u20090.046]. This parameter was identified as a risk factor for POD. Patients in the open surgery group had increased interleukin 1\u03b2 and neurofilament light chain in the blood. However, there was no change in these biomarkers in the cerebrospinal fluids at 10 and 24\u2009h after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that surgery is a major contributor to POD, inflammatory response, and neuronal injury. Low body temperature at the end of surgery is a potential risk factor for POD in patients with open repair for thoracic aortic aneurysm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70509","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:33:37Z","timestamp":1752064417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgery May Be a Major Contributor for Postoperative Delirium in Patients With Elective Thoracic Aortic Aneurysm Procedures"],"prefix":"10.1111","volume":"31","author":[{"given":"Lucas G.","family":"Fernandez","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiran","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah S.","family":"Terkawi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Yerra","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-5047","authenticated-orcid":false,"given":"Zhiyi","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"Ambulatory Surgery Data From Hospitals and Ambulatory Surgery Centers: United States, 2010","volume":"102","author":"Hall M. 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