{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:30:23Z","timestamp":1784874623703,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20377"],"award-info":[{"award-number":["U22A20377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2024ZZTS0954"],"award-info":[{"award-number":["2024ZZTS0954"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["CB\u2010C2022"],"award-info":[{"award-number":["CB\u2010C2022"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to characterize the topological changes in glucose metabolism covariance networks in amyotrophic lateral sclerosis (ALS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the interregional coordination of <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET data to examine topological alterations in individualized glucose metabolism covariance networks in 127 ALS patients compared to 128 healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HC, ALS patients showed reduced small\u2010worldness (lower normalized clustering coefficient, higher normalized characteristic path length) and decreased global and local efficiency, suggesting impaired global integration and local segregation. These network metrics correlated with disease progression and motor function. Regionally, altered degree centrality affected motor and default mode networks, and related to GABAa and mGluR5 receptor expression. Transcriptomic associations further linked these changes to immune function, synaptic signaling, and protein regulation. Bidirectional shifts in connectivity strength were observed, with both increased connectivity and disease progression independently predicting reduced survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings may provide valuable biomarkers for monitoring the progression of ALS and suggest potential mechanistic pathways for the development of innovative therapeutic strategies for this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70537","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T06:25:27Z","timestamp":1753770327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Xin","family":"Jin","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-052X","authenticated-orcid":false,"given":"Xueying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital, Central South University  Changsha Hunan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pubing","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Li","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Qiu","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Chen","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9641-3829","authenticated-orcid":false,"given":"Jinfan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital, Central South University  Changsha Hunan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital, Central South University  Changsha Hunan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases)  Nanchang Jiangxi P.\u00a0R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-2196","authenticated-orcid":false,"given":"Alessandro","family":"Grecucci","sequence":"additional","affiliation":[{"name":"Department of Psychology and Cognitive Sciences (DiPSCo) University of Trento  Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-4899","authenticated-orcid":false,"given":"Yuanchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China  Chengdu Sichuan P. R. China"},{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan P.\u00a0R. China"},{"name":"College of Health Solutions Arizona State University  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5117-5204","authenticated-orcid":false,"given":"Junling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases)  Nanchang Jiangxi P.\u00a0R. China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases  Changsha Hunan P. R. China"},{"name":"National Clinical Research Center for Geriatric Diseases, Xiangya Hospital Central South University  Changsha Hunan P. R. China"},{"name":"Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South University  Changsha Hunan P.\u00a0R.\u00a0China"},{"name":"Center for Medical Genetics, School of Life Sciences Central South University  Changsha Hunan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1981","authenticated-orcid":false,"given":"Xiaoping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Three Gorges Hospital, Chongqing University  Chongqing P. R. China"},{"name":"Clinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC) Chongqing University Three Gorges Hospital, Chongqing University  Chongqing P. R. China"},{"name":"School of Medicine Chongqing University  Chongqing P. R. China"},{"name":"FuRong Laboratory  Changsha Hunan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-7182","authenticated-orcid":false,"given":"Lena","family":"Palaniyappan","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Blair","family":"Braden","sequence":"additional","affiliation":[{"name":"College of Health Solutions Arizona State University  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic Lateral Sclerosis","volume":"377","author":"Kiernan M. C.","year":"2011","journal-title":"Lancet"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrneurol.2014.184","article-title":"The Phenotypic Variability of Amyotrophic Lateral Sclerosis","volume":"10","author":"Swinnen B.","year":"2014","journal-title":"Nature Reviews Neurology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jnnp-2013-307223","article-title":"Cognitive Correlates in Amyotrophic Lateral Sclerosis: A Population\u2010Based Study in Italy","volume":"86","author":"Montuschi A.","year":"2015","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S1474-4422(13)70026-7","article-title":"Changes in Cognition and Behaviour in Amyotrophic Lateral Sclerosis: Nature of Impairment and Implications for Assessment","volume":"12","author":"Goldstein L. H.","year":"2013","journal-title":"Lancet Neurology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/hbm.24609","article-title":"Precentral Degeneration and Cerebellar Compensation in Amyotrophic Lateral Sclerosis: A Multimodal MRI Analysis","volume":"40","author":"Qiu T.","year":"2019","journal-title":"Human Brain Mapping"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1212\/WNL.0b013e31829c5eee","article-title":"Multiparametric MRI Study of ALS Stratified for the C9orf72 Genotype","volume":"81","author":"Bede P.","year":"2013","journal-title":"Neurology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1212\/01.wnl.0000167602.38643.29","article-title":"A Voxel\u2010Based Morphometry Study of Patterns of Brain Atrophy in ALS and ALS\/FTLD","volume":"65","author":"Chang J. L.","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s00702-021-02413-0","article-title":"Between\u2010Sex Variability of Resting State Functional Brain Networks in Amyotrophic Lateral Sclerosis (ALS)","volume":"128","author":"Trojsi F.","year":"2021","journal-title":"Journal of Neural Transmission"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00415-022-11445-9","article-title":"Brain Metabolic Differences Between Pure Bulbar and Pure Spinal ALS: A 2\u2010[18F]FDG\u2010PET Study","volume":"270","author":"Canosa A.","year":"2023","journal-title":"Journal of Neurology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00259-018-4246-2","article-title":"Testing the Diagnostic Accuracy of [18F]FDG\u2010PET in Discriminating Spinal\u2010 and Bulbar\u2010Onset Amyotrophic Lateral Sclerosis","volume":"46","author":"Sala A.","year":"2019","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1007\/s00259-021-05668-7","article-title":"Amyotrophic Lateral Sclerosis With SOD1 Mutations Shows Distinct Brain Metabolic Changes","volume":"49","author":"Canosa A.","year":"2022","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2018.101619","article-title":"Abnormal Topological Organization of Structural Covariance Networks in Amyotrophic Lateral Sclerosis","volume":"21","author":"Zhang Y.","year":"2018","journal-title":"NeuroImage: Clinical"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41380-022-01452-7","article-title":"Subtly Altered Topological Asymmetry of Brain Structural Covariance Networks in Autism Spectrum Disorder Across 43 Datasets From the ENIGMA Consortium","volume":"27","author":"Sha Z.","year":"2022","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1007\/s00259-024-06762-2","article-title":"Individual Cerebellar Metabolic Connectome in Patients With MTLE and NTLE Associated With Surgical Prognosis","volume":"51","author":"Tang Y.","year":"2024","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00429-014-0772-2","article-title":"Abnormalities in Structural Covariance of Cortical Gyrification in Schizophrenia","volume":"220","author":"Palaniyappan L.","year":"2015","journal-title":"Brain Structure & Function"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single\u2010Subject Brain","volume":"15","author":"Tzourio\u2010Mazoyer N.","year":"2002","journal-title":"NeuroImage"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/21678421.2015.1049183","article-title":"A Revision of the El Escorial Criteria\u20132015","volume":"16","author":"Ludolph A.","year":"2015","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.0030017","article-title":"Efficiency and Cost of Economical Brain Functional Networks","volume":"3","author":"Achard S.","year":"2007","journal-title":"PLoS Computational Biology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hbm.23452","article-title":"White Matter Structural Network Abnormalities Underlie Executive Dysfunction in Amyotrophic Lateral Sclerosis","volume":"38","author":"Dimond D.","year":"2017","journal-title":"Human Brain Mapping"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"e2552","DOI":"10.1212\/WNL.0000000000010731","article-title":"Structural and Functional Brain Connectome in Motor Neuron Diseases: A Multicenter MRI Study","volume":"95","author":"Basaia S.","year":"2020","journal-title":"Neurology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae222","article-title":"Different Patterns of Structural Network Impairments in Two Amyotrophic Lateral Sclerosis Subtypes Driven by 18F\u2010Fluorodeoxyglucose Positron Emission Tomography\/Magnetic Resonance Hybrid Imaging","volume":"6","author":"Feng F.","year":"2024","journal-title":"Brain Communications"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40035-021-00255-0","article-title":"Disruption of the White Matter Structural Network and Its Correlation With Baseline Progression Rate in Patients With Sporadic Amyotrophic Lateral Sclerosis","volume":"10","author":"Li W.","year":"2021","journal-title":"Translational Neurodegeneration"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1007\/s00259-016-3434-1","article-title":"Amyloid\u2010 and FDG\u2010PET Imaging in Amyotrophic Lateral Sclerosis","volume":"43","author":"Mat\u00edas\u2010Guiu J. A.","year":"2016","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/01.wnl.0000437313.80913.2c","article-title":"Basal Ganglia Involvement in Amyotrophic Lateral Sclerosis","volume":"81","author":"Bede P.","year":"2013","journal-title":"Neurology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00401-011-0932-x","article-title":"Microglial Activation and TDP\u201043 Pathology Correlate With Executive Dysfunction in Amyotrophic Lateral Sclerosis","volume":"123","author":"Brettschneider J.","year":"2012","journal-title":"Acta Neuropathologica"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jamaneurol.2014.62","article-title":"Value of18 Fluorodeoxyglucose\u2013Positron\u2010Emission Tomography in Amyotrophic Lateral Sclerosis: A Prospective Study","volume":"71","author":"Van Laere K.","year":"2014","journal-title":"JAMA Neurology"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.neuro.31.060407.125547","article-title":"Descending Pathways in Motor Control","volume":"31","author":"Lemon R. N.","year":"2008","journal-title":"Annual Review of Neuroscience"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1093\/brain\/awt243","article-title":"Executive Deficits, Not Processing Speed Relates to Abnormalities in Distinct Prefrontal Tracts in Amyotrophic Lateral Sclerosis","volume":"136","author":"Pettit L. D.","year":"2013","journal-title":"Brain"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroimage.2013.10.003","article-title":"Lateralized Alpha\u2010Band Cortical Networks Regulate Volitional Modulation of Beta\u2010Band Sensorimotor Oscillations","volume":"87","author":"Vukeli\u0107 M.","year":"2014","journal-title":"NeuroImage"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1093\/emboj\/18.16.4361","article-title":"Metal Ion Transporters and Homeostasis","volume":"18","author":"Nelson N.","year":"1999","journal-title":"EMBO Journal"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium Signaling","volume":"131","author":"Clapham D. E.","year":"2007","journal-title":"Cell"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune Function of Astrocytes","volume":"36","author":"Dong Y.","year":"2001","journal-title":"Glia"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: A Sensor for Pathological Events in the CNS","volume":"19","author":"Kreutzberg G. W.","year":"1996","journal-title":"Trends in Neurosciences"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1002\/hbm.22814","article-title":"Amyotrophic Lateral Sclerosis Affects Cortical and Subcortical Activity Underlying Motor Inhibition and Action Monitoring: ALS and Motor Inhibition","volume":"36","author":"Mohammadi B.","year":"2015","journal-title":"Human Brain Mapping"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1007\/s00330-015-3671-x","article-title":"Altered Cortical Activation During Action Observation in Amyotrophic Lateral Sclerosis Patients: A Parametric Functional MRI Study","volume":"25","author":"Li H.","year":"2015","journal-title":"European Radiology"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.2010.05444.x","article-title":"The Anatomy of Language: A Review of 100 fMRI Studies Published in 2009","volume":"1191","author":"Price C. J.","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102509","article-title":"Progression of Brain Functional Connectivity and Frontal Cognitive Dysfunction in ALS","volume":"28","author":"Castelnovo V.","year":"2020","journal-title":"NeuroImage: Clinical"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.biopsych.2018.06.012","article-title":"The Triple Network Model, Insight, and Large\u2010Scale Brain Organization in Autism","volume":"84","author":"Menon V.","year":"2018","journal-title":"Biological Psychiatry"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/ene.14717","article-title":"Structural and Functional Underpinnings of Precentral Abnormalities in Amyotrophic Lateral Sclerosis","volume":"28","author":"Cheng L.","year":"2021","journal-title":"European Journal of Neurology"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative Stress, Glutamate, and Neurodegenerative Disorders","volume":"262","author":"Coyle J. T.","year":"1993","journal-title":"Science"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000089620","article-title":"Excitotoxicity and Amyotrophic Lateral Sclerosis","volume":"2","author":"Van Cutsem P.","year":"2005","journal-title":"Neurodegenerative Diseases"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14728222.2018.1439923","article-title":"TDP\u201043 Post\u2010Translational Modifications in Health and Disease","volume":"22","author":"Buratti E.","year":"2018","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37630-6","article-title":"Integrated Transcriptome Landscape of ALS Identifies Genome Instability Linked to TDP\u201043 Pathology","volume":"14","author":"Ziff O. J.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1093\/hmg\/ddt243","article-title":"Drosophila TDP\u201043 Dysfunction in Glia and Muscle Cells Cause Cytological and Behavioural Phenotypes That Characterize ALS and FTLD","volume":"22","author":"Diaper D. C.","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.598474","article-title":"Resting State Functional Connectivity Is Decreased Globally Across the C9orf72 Mutation Spectrum","volume":"11","author":"Smallwood Shoukry R. F.","year":"2020","journal-title":"Frontiers in Neurology"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroimage.2014.11.024","article-title":"Beyond the Word and Image: Characteristics of a Common Meaning System for Language and Vision Revealed by Functional and Structural Imaging","volume":"106","author":"Jouen A. L.","year":"2015","journal-title":"NeuroImage"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2015.04.050","article-title":"The BDNF Val66Met Polymorphism, Resting\u2010State Hippocampal Functional Connectivity and Cognitive Deficits in Acute Late\u2010Onset Depression","volume":"183","author":"Yin Y.","year":"2015","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012595","article-title":"Machine Learning Suggests Polygenic Risk for Cognitive Dysfunction in Amyotrophic Lateral Sclerosis","volume":"13","author":"Placek K.","year":"2021","journal-title":"EMBO Molecular Medicine"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.neuron.2016.04.018","article-title":"The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others","volume":"90","author":"Apps M. A. J.","year":"2016","journal-title":"Neuron"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111358118","article-title":"The Middle Cingulate Cortex and Dorso\u2010Central Insula: A Mirror Circuit Encoding Observation and Execution of Vitality Forms","volume":"118","author":"Di Cesare G.","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1093\/brain\/awl254","article-title":"Structural Anatomy of Empathy in Neurodegenerative Disease","volume":"129","author":"Rankin K. P.","year":"2006","journal-title":"Brain"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:13:15Z","timestamp":1753783995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/cns.70537"],"URL":"https:\/\/doi.org\/10.1111\/cns.70537","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70537"}}