{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:05:42Z","timestamp":1784113542423,"version":"3.55.0"},"reference-count":75,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372582"],"award-info":[{"award-number":["82372582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with mild cognitive impairment (MCI) often exhibit progressive deficits in bimanual coordination and fine motor dexterity. However, the neural mechanisms underlying these motor impairments remain poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional study employed functional near\u2010infrared spectroscopy (fNIRS) to examine cortical hemodynamic responses during fine motor tasks in MCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty individuals with MCI and 40 age\u2010, sex\u2010, and education\u2010matched healthy controls (HCs) performed the Nine\u2010Hole Peg Test (NHPT) while fNIRS monitored oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) responses in the prefrontal cortex (PFC), sensorimotor cortex (SMC), and visual cortex (VC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HCs, individuals with MCI exhibited significantly impaired NHPT performance, accompanied by reduced HbO responses in the right PFC and SMC during task performance. Furthermore, stepwise discriminant analysis identified a combination of right SMC HbO levels and NHPT scores as a significant predictor for distinguishing MCI from HCs, achieving an area under the curve (AUC) of 80.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings provide novel evidence linking aberrant cortical hypoactivation in the motor and executive control regions to fine motor impairments in individuals with MCI, suggesting disrupted motor\u2010cognitive integration in early cognitive decline. The integration of fNIRS\u2010derived hemodynamic responses with functional motor assessments offers a promising non\u2010invasive approach for MCI detection and personalized rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>This study was registered with the Chinese Clinical Trial Registry (Registration No. ChiCTR2400082429) on March 28, 2024<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70547","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T06:25:44Z","timestamp":1753770344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment"],"prefix":"10.1111","volume":"31","author":[{"given":"Han","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taicheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"School of Psychology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-8363","authenticated-orcid":false,"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Psychology Shanghai Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-945X","authenticated-orcid":false,"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Psychology Shanghai Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-4193","authenticated-orcid":false,"given":"Hanjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-9562","authenticated-orcid":false,"given":"Ying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"10440","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","article-title":"Global Incidence, Prevalence, Years Lived With Disability (Ylds), Disability\u2010Adjusted Life\u2010Years (Dalys), and Healthy Life Expectancy (Hale) for 371 Diseases and Injuries in 204 Countries and Territories and 811 Subnational Locations, 1990\u20132021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Ferrari A. 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