{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:10:11Z","timestamp":1754161811811,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2502100"],"award-info":[{"award-number":["2021YFC2502100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aimed to investigate the role of <jats:italic>NUS1<\/jats:italic> variants in Parkinson's disease (PD) progression and evaluate plasma Nogo\u2010B receptor (NgBR) as a potential biomarker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 228 PD patients, including 38 with <jats:italic>NUS1<\/jats:italic> variants (<jats:italic>NUS1<\/jats:italic>\u2010PD) and 190 without (GU\u2010PD), and all underwent at least two follow\u2010up visits. Linear mixed\u2010effects models assessed motor and non\u2010motor symptom progression. Plasma NgBR levels were measured in PD, Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), and healthy controls (HC), and receiver operating characteristic curve analysis evaluated its diagnostic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>NUS1<\/jats:italic>\u2010PD demonstrated an earlier age at onset and more severe motor features than GU\u2010PD at baseline. Longitudinal analyses showed similar progression rates of UPDRS III and H&amp;Y stage (off\u2010medication) in <jats:italic>NUS1<\/jats:italic>\u2010PD and GU\u2010PD, but a slower progression rate of urinary function in <jats:italic>NUS1<\/jats:italic>\u2010PD (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). Plasma NgBR levels were higher in PD than in HC, MSA, and PSP, with AUC values of 0.6832, 0.6716, and 0.6628, respectively. Plasma NgBR was associated with UPDRS III (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and cognitive impairment (<jats:italic>p<\/jats:italic>\u2009=\u20090.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>NUS1<\/jats:italic> variants show no impact on PD progression, while plasma NgBR may serve as a potential biomarker for PD diagnosis and clinical characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70549","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T06:24:10Z","timestamp":1753770250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Progression of <scp><i>NUS1<\/i><\/scp>\u2010Associated Parkinson's Disease and the Diagnostic Potential of Plasma <scp>NgBR<\/scp>"],"prefix":"10.1111","volume":"31","author":[{"given":"Lizhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Radiology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5213-9984","authenticated-orcid":false,"given":"Xuxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-9967","authenticated-orcid":false,"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-8345","authenticated-orcid":false,"given":"Qiying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-806X","authenticated-orcid":false,"given":"Jinchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Centre for Medical Genetics Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-3928","authenticated-orcid":false,"given":"Jifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Centre for Medical Genetics Central South University  Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases  Changsha 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