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Nearly 60% of patients with OSA suffer from a variety of impaired cognitive functions, including attention, working memory, and episodic memory, and are susceptible to mood disorders such as depression and anxiety. However, it remains largely unexplored regarding the features of the electroencephalography (EEG) microstates of these patients and the potential association between the EEG microstates and the cognitive impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, we performed polysomnography (PSG) on 70 patients who were recruited from the Department of Neurology and subsequently categorized into the OSA group (44 patients) and the non\u2010OSA group (26 patients). We collected and analyzed their demographic information, blood and body fluid specimens, EEG alpha peak frequency, and EEG microstates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Compared with the non\u2010OSA group, the OSA group reported more cases of comorbid anxiety symptoms (58.5% vs. 29%), and scored significantly lower in the word classification test. Of note, compared with the non\u2010OSA counterparts, the OSA patients displayed markedly more microstate A, a significantly higher rate of B to A microstate conversion, and drastically lower Delta and Theta power at the F7\u2010AV position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings confirm that OSA may affect sleep quality and cognitive function by influencing EEG activity and microstates, which highlights a potential EEG network mechanism for OSA\u2010induced cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70553","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:06:38Z","timestamp":1754481998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Obstructive Sleep Apnea on Cognition: An Analysis of Electroencephalography Microstates and Alpha Peak 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