{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:08:22Z","timestamp":1785146902319,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effects and mechanisms of S\u2010adenosylmethionine (SAM) from deer antler on improving depression\u2010like behaviors in chronic unpredictable mild stress (CUMS) mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CUMS method was used to establish a mouse depression model. The relationship between SAM and HIF\u20101\u03b1 was analyzed by small molecule\u2010protein docking and molecular dynamics simulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Network pharmacology analysis showed that the effect of SAM is related to HIF\u20101\u03b1. When shRNA\u2010HIF\u20101\u03b1 was used to silence the expression of HIF\u20101\u03b1, the effect of SAM was inhibited. The improvement of depression\u2010like behaviors in mice was not significant, and inflammatory factors were no longer further downregulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SAM can improve depression\u2010like behaviors in CUMS mice and enhance their mobility. SAM inhibits neuroinflammation and glycolysis, and also suppresses the activation of microglia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70569","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:39:39Z","timestamp":1757500779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deer Antler S\u2010Adenosylmethionine Ameliorates Depression\u2010Like Behaviors and Neuroinflammation in\n                    <scp>CUMS<\/scp>\n                    Mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Yongjian","family":"Liu","sequence":"first","affiliation":[{"name":"Interventional Department First Affiliated Hospital of Dalian Medical University  Dalian 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