{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:48:28Z","timestamp":1790732908768,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171207"],"award-info":[{"award-number":["82171207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231246"],"award-info":[{"award-number":["BK20231246"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study is to investigate the role of Endothelin\u2010converting enzyme\u2010like 1 (ECEL1) in neuropathic pain (NP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The expression of ECEL1 was modulated by injecting adeno\u2010associated virus 5 (AAV5) carrying Ecel1 shRNA or full\u2010length Ecel1 into the dorsal root ganglion (DRG) of mice with a chronic constriction injury (CCI) model. Then, various nociceptive responses were evaluated. Additionally, leukemia inhibitory factor (LIF) was intrathecally injected, or its function was blocked, to observe the changes in ECEL1 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings demonstrate that downregulating ECEL1 expression alleviates CCI\u2010induced pain and reduces the hyperexcitability of injured DRG neurons, which is achieved by inhibiting sympathetic sprouting in the DRG. Conversely, overexpressing ECEL1 in DRG neurons leads to pain hypersensitivity. Additionally, we observed that LIF upregulated ECEL1 expression, while blocking LIF reduced ECEL1 expression and mitigated CCI\u2010induced nociception in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ECEL1 promotes hyperalgesia following CCI and is regulated by LIF, suggesting it could be a new target for NP treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70578","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:28:37Z","timestamp":1756970917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endothelin\u2010Converting Enzyme\u2010Like 1 Regulated by\n                    <scp>LIF<\/scp>\n                    Contributes to Chronic Constriction Injury\u2010Induced Neuropathic Pain in Mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Feng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Orthopedics Jiangsu Provincial Corps Hospital, Chinese People's Armed Police Force  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology Jiangsu Provincial Corps Hospital, Chinese People's Armed Police Force  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Jiangsu Provincial Corps Hospital, Chinese People's Armed Police Force  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8204-512X","authenticated-orcid":false,"given":"Chen","family":"Gu","sequence":"additional","affiliation":[{"name":"Clinical Medical College Yangzhou University  Yangzhou 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