{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:49:12Z","timestamp":1793029752538,"version":"4.5.0"},"reference-count":97,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1823"],"award-info":[{"award-number":["2024NSFSC1823"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0613"],"award-info":[{"award-number":["2022YFS0613"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral ischemia\u2010reperfusion injury (CIRI) arises after blood flow restoration in stroke, where reperfusion paradoxically triggers mitochondrial dysfunction, apoptosis, inflammation, and oxidative stress. Dynamin\u2010related protein 1 (Drp1), a regulator of mitochondrial fission, amplifies these cascades by promoting apoptosis, inflammatory signaling, and calcium imbalance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review synthesizes recent studies on Drp1 in CIRI, focusing on its regulatory roles in mitochondrial dynamics and neuronal injury, and evaluating therapeutic strategies through pharmacological and genetic modulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence shows Drp1 inhibition mitigates CIRI in preclinical models by restoring mitochondrial homeostasis, reducing oxidative stress, and improving neuronal survival. Promising interventions include selective inhibitors and genetic approaches, though challenges remain regarding drug specificity, delivery efficiency, and long\u2010term safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Drp1 is central to CIRI pathology and represents a promising therapeutic target. Future work should prioritize advanced delivery systems and safer, more selective Drp1 modulators to enable clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70590","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:25:56Z","timestamp":1756445156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Targeting Drp1 in Cerebral Ischemia\u2013Reperfusion Injury: Mechanisms and Therapeutic Implications"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-642X","authenticated-orcid":false,"given":"Mengnan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, the Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixue","family":"Yin","sequence":"additional","affiliation":[{"name":"Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binru","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Minzu Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Qiu","sequence":"additional","affiliation":[{"name":"Luhuo County Niba Township Health Center  Luhuo Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-7778","authenticated-orcid":false,"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-3863","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489241"},{"key":"e_1_2_13_3_1","first-page":"1","article-title":"Mitochondrial Dynamics and Quality Control Regulate Proteostasis in Neuronal Ischemia\u2010Reperfusion","volume":"16","author":"Fogo G. 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