{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:29:10Z","timestamp":1785281350502,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The hormone adiponectin impacts various facets of brain function, including neurogenesis, energy homeostasis, and synaptic processes. The use of adiponectin or adiponectin receptor agonists may protect against Alzheimer's disease (AD) and reduce AD pathology. Here, we investigated the ability of the adiponectin receptor agonist, AdipoRon, to restore synaptic function in an AD mouse model and the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Acute hippocampal slices from 3xTg\u2010AD mice and age\u2010matched controls were used to evaluate the ability of AdipoRon to rescue synaptic deficits in an AD model. Slices were incubated in AdipoRon or other pharmacological agents, followed by electrophysiological field recordings to evaluate synaptic function and plasticity. Signaling pathway alterations were evaluated by Western blot, with a focus on AMP\u2010activated protein kinase (AMPK) signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incubation of hippocampal slices with AdipoRon ameliorated long\u2010term potentiation (LTP) and basal synaptic transmission deficits in 3xTg\u2010AD mice. AdipoRon was unable to restore these parameters in the presence of the AMPK inhibitor, Compound C. AdipoRon altered presynaptic parameters by a mechanism that did not appear to be solely dependent on AMPK. AdipoRon slice incubation was associated with activation of AMPK, inhibition of GSK3\u03b2, and altered glutamatergic receptor subunit phosphorylation based on Western blot analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Activation of adiponectin receptors restores synaptic function in an AD model in part through AMPK signaling. These results warrant further investigation into adiponectin receptor agonists as a novel approach for AD prevention or treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70616","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:36:51Z","timestamp":1758605811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adiponectin Receptor Agonist Ameliorates Synaptic Dysfunction in\n                    <scp>3xTg<\/scp>\n                    Alzheimer's Disease Mouse Model by Activation of\n                    <scp>AMPK<\/scp>"],"prefix":"10.1111","volume":"31","author":[{"given":"Jenna","family":"Bloemer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Larkin University  Miami Florida USA"},{"name":"Department of Drug Discovery and Development Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka D.","family":"Pinky","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Suppiramaniam","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development Auburn University  Auburn Alabama USA"},{"name":"Center for Neuroscience Initiative Auburn University  Auburn Alabama USA"},{"name":"Department of Molecular and Cellular Biology, College of Science and Mathematics Kennesaw State University  Kennesaw Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development Auburn University  Auburn Alabama USA"},{"name":"Center for Neuroscience Initiative Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415219111"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1029"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.436"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010151116"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001107\u20103"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012632\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13514"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11708"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.23"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006745"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010016\u20100136\u2010x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010019\u20101492\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00778"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEULET.2017.10.042"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045509\u20100"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215063"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.753525"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.10.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.12.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135700"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13665"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.07.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010011\u20100805\u20104"},{"key":"e_1_2_10_25_1","first-page":"11637","article-title":"Cooperative Interactions Among Afferents Govern the Induction of Homosynaptic Long\u2010Term Depression in the Hippocampus (Associativity\/Picrotoxin\/N\u2010Methyl\u2010D\u2010Aspartate)","volume":"92","author":"Kerr D. 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