{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:38:14Z","timestamp":1771652294103,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101203"],"award-info":[{"award-number":["2021YFA1101203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Naringin, a flavanone glycoside (naringenin 7\u2010O\u2010neohesperidose), exhibits a broad range of pharmacological activities, including neuroprotection. However, its effects on autistic\u2010like behavior have not been extensively studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this investigation, we utilized the autistic BTBR T\u2009+\u2009tf\/J (BTBR) mice to conduct behavioral tests assessing autistic\u2010like phenotypes. We evaluated hippocampal neurogenesis through immunofluorescence and employed molecular biological techniques, along with RNA sequencing, to elucidate the underlying molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings revealed that the administration of naringin alleviated autism\u2010associated behaviors in BTBR mice. RNA sequencing analysis indicated that naringin facilitated the recovery of impaired hippocampal neurogenesis in these mice, as evidenced by an increase in doublecortin (DCX)\u2010positive cells and neuronal progenitor cells (NPCs) in the dentate gyrus (DG). Furthermore, we confirmed that the cannabinoid receptor type\u20101 (CB1) plays a role in the therapeutic effects of naringin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research highlights the potential of naringin as a promising treatment option for autism spectrum disorder (ASD) and suggests that targeting hippocampal neurogenesis through the CB1 receptor may be an effective strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70654","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:38:59Z","timestamp":1764391139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Naringin Alleviates Autistic\u2010Like Behaviors in\n                    <scp>BTBR<\/scp>\n                    Mice Through Cannabinoid Receptor Type 1\u2010Mediated Restoration of Hippocampal Neurogenesis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9610-1975","authenticated-orcid":false,"given":"Yulong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Military Cognitive Psychology, School of Psychology Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Department of Histology and Embryology Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-3413","authenticated-orcid":false,"given":"Meiling","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Military Cognitive Psychology, School of Psychology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinggao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of 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(Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Military Cognitive Psychology, School of Psychology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Military Cognitive Psychology, School of Psychology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Military Cognitive Psychology, School of Psychology Third Military Medical University (Army Medical University)  Chongqing 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