{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:40:34Z","timestamp":1793504434884,"version":"4.5.0"},"reference-count":272,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130060"],"award-info":[{"award-number":["32130060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401633"],"award-info":[{"award-number":["82401633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20232023"],"award-info":[{"award-number":["BK20232023"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The AMPK\/SIRT1\/PGC\u20101\u03b1 pathway serves as a central regulator of cellular energy homeostasis, coordinating metabolic stress responses, epigenetic modifications, and transcriptional programs. Its dysfunction is implicated in the pathogenesis of a wide spectrum of complex modern diseases, spanning neurodegeneration, metabolic syndromes, and chronic inflammatory conditions. This review examines the pathway's role as an integrative hub and its potential as a therapeutic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We synthesize current mechanistic evidence from molecular, cellular, and preclinical studies to elucidate the pathway's operational logic and the consequences of its dysregulation. The analysis is structured around key disease paradigms\u2014including Alzheimer's disease, Parkinson's disease, diabetes, cardiovascular injury, stroke, and chronic kidney disease\u2014to dissect its tissue\u2010specific pathophysiological impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The AMPK\/SIRT1\/PGC\u20101\u03b1 axis operates through a core positive feedback loop: AMPK activation elevates NAD+, thereby activating SIRT1, which in turn deacetylates and activates PGC\u20101\u03b1 to drive mitochondrial biogenesis and function, further reinforcing SIRT1 activity. Disruption of this cascade manifests in disease\u2010specific mechanisms: promoting A\u03b2 production via BACE1\/\u03b3\u2010secretase in Alzheimer's; impairing \u03b1\u2010synuclein clearance in Parkinson's; disrupting GLUT4 translocation and insulin signaling in diabetes; exacerbating oxidative damage and mitochondrial dysfunction in cardiovascular and neuronal injury; and accelerating fibrosis and sustained inflammation in renal and pulmonary diseases via NLRP3 and TGF\u2010\u03b2\/Smad3 signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The AMPK\/SIRT1\/PGC\u20101\u03b1 pathway represents a cornerstone target at the intersection of metabolism, aging, and disease. Current therapeutic strategies\u2014including pharmacological activators (e.g., metformin, SRT1720), natural compounds (e.g., resveratrol), lifestyle interventions (e.g., exercise, caloric restriction), and emerging technologies (e.g., gene editing, exosomal miRNAs)\u2014offer multidimensional avenues for intervention. Future research must prioritize elucidating tissue\u2010specific regulatory mechanisms, such as AMPK isoform diversity and PGC\u20101\u03b1 interactome dynamics, to enable precision therapeutics and successful clinical translation for a range of complex disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70657","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T10:12:27Z","timestamp":1763719947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":231,"title":["AMPK\/SIRT1\/PGC\u20101\u03b1 Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy"],"prefix":"10.1111","volume":"31","author":[{"given":"Junyang","family":"Chen","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Yao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yi","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xue","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-4761","authenticated-orcid":false,"given":"Yuntian","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City  Changshu Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-1561","authenticated-orcid":false,"given":"Hualin","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00547-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116476"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.04.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.11.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.947387"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2024.08.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116615"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116932"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115543"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166815"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051075"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116053"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.09.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-024-00536-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01454-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32253"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4553"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49426"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081079"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2676"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16810"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44242-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301848"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2259216"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119824119"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00848-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02079-x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.12.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5582"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201302734"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.16"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116880"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605488200"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.09.079"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15852"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212281"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.653557"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.134890"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154589"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00648-y"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1749490"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"issue":"4","key":"e_1_2_10_45_1","first-page":"425","article-title":"Research Progress in the Regulation of Autophagy and Mitochondrial Homeostasis by AMPK Signaling Channels","volume":"36","author":"Ruan P.","year":"2024","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1186231"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1448535"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.920278"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.01.012"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09869-2"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06232-x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203949"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.4.156"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad504"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133153"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110398"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10315-7"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24061"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03340-w"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111215"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170703113212"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1452696"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.871357"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.027"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.10.010"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63824"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11071012"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00082.2017"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0454"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.05.011"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy033"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00886-3"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2020.1807850"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02250-8"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.007"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101444"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174858"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01258"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411002109"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200928155728"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14763"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116373"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1728095"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.2013"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802187200"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.4161\/15548627.2014.984271"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180902"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119425"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00030-2"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322338"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123665"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171296"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.03.021"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00961-z"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120132"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0216"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073487"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300758"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071012"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020303"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03806-w"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.09.022"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.10.004"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081183"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16151"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56070"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1936359"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.668500"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14692"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102545"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12839"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172847"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.03.004"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.317957"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00102"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04369-z"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1344276"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28528"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0592"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO00095J"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5566053"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.636172"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz324"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68227-8"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.03.029"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60481-9"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02403-5"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v11.i4.115"},{"issue":"3","key":"e_1_2_10_132_1","article-title":"AMPK Signaling Mediates Synphilin\u20101\u2010Induced Hyperphagia and Obesity in Drosophila","volume":"134","author":"Liu J.","year":"2021","journal-title":"Journal of Cell Science"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118828"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2087595"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113949"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.81"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111249"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.62556"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277280"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300370"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00026.2016"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11162529"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v66.7909"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.09.001"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29366"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.04.005"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.321850"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03697-8"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6580"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02586-y"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156743"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155649"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2022.02.005"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105743"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111205"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202143"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30875"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12818"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.645041"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.616813"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1320271"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137420"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200429004242"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04398-9"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S484969"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.07.001"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036054"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.09.006"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1374-y"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114317"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00860-0"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02289-7"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112257"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169104"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2022.120101"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02174-3"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00084"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101792"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110723"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153884"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117672"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1224964"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115407"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091686"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116799"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.859723"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2524-6"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad076"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135235"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153232"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1499012"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2403653"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156411"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86905-9"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2024.112409"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514532"},{"issue":"5","key":"e_1_2_10_197_1","first-page":"969","article-title":"Shenqi Buzhong Formula Ameliorates Mitochondrial Dysfunction in a Rat Model of Chronic Obstructive Pulmonary Disease by Activating the AMPK\/SIRT1\/PGC\u20101\u03b1 Pathway","volume":"45","author":"Zhang L.","year":"2025","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70566"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00323.2013"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2024.04.003"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320888"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9173"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2015.78.1.8"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00249.2012"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091071"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2025.2459597"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09752-7"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2292256"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0242-2"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0019-2"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110628"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1743911"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.09.074"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12585"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051095"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01895.x"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107925"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049935"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00648.2009"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102534"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2024.159453"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102745"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113756"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091720"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134331"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171448"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13121069"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101936"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7584691"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.02.007"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.02.027"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104476"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.108297"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107036"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2024.159570"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112838"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120064"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114515"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05060-7"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106205"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112326"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.68873"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16172878"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108342"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.01.018"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11030448"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v64.3668"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-060721-095517"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204750120"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119579"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13114"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103046"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7914"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30977-7"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70030"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03655-2"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103222"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13177"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02563-9"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.049"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204690"},{"key":"e_1_2_10_262_1","first-page":"1","article-title":"AMPK\u2010Activated BAP1 Regulates pVHL Stability and Tumor\u2010Suppressive Functions","author":"Li M.","year":"2025","journal-title":"Cell Death and Differentiation"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.001"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906606106"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11066"},{"key":"e_1_2_10_266_1","first-page":"1","article-title":"Alpha\u2010Ketoglutarate Dictates AMPK Protein Synthesis for Energy Sensing in Human Cancers","author":"Mi W.","year":"2025","journal-title":"Nature Chemical Biology"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.103186"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.07.023"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-119057"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.325262"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102288"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.09.004"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133982"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:46:43Z","timestamp":1764312403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":272,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/cns.70657"],"URL":"https:\/\/doi.org\/10.1111\/cns.70657","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70657"}}