{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:50:41Z","timestamp":1764312641414,"version":"3.46.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["22CXRC0178"],"award-info":[{"award-number":["22CXRC0178"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Focal cortical dysplasia (FCD) is a leading cause of drug\u2010resistant epilepsy, characterized by cortical malformations and aberrant neuronal\u2010glial interactions. Recently, the role of Liver X Receptor Beta (LXR\u03b2) in neurodevelopment has attracted considerable attention, although its involvement in FCD pathogenesis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established a freezing lesion\u2010cortical dysplasia (FL\u2010CD) model in neonatal mice to mimic the pathological features of FCD. We evaluated the expression of LXR\u03b2 and its downstream target, brain lipid\u2010binding protein (BLBP), using immunohistochemistry and Western blot analysis. LXR\u03b2 activation and inhibition were pharmacologically modulated to assess their effects on glial migration, differentiation and cortical electrophysiology. Electroencephalogram (EEG) recordings were analyzed for power spectral density and functional connectivity to further investigate alterations in cortical network activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LXR\u03b2 and BLBP were significantly downregulated in the lesion cortex during early developmental stages. Activation of LXR\u03b2 reduced gliosis, promoted astrocytic differentiation, and modified cortical oscillatory activity, as evidenced by enhanced \u03b1 power and gamma band functional connectivity, along with adjustments in the theta\/beta ratio. In contrast, inhibition of LXR\u03b2 exacerbated gliosis and disrupted cortical network synchronization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that LXR\u03b2 plays a critical role in regulating glial migration, differentiation and cortical network remodeling in the FL\u2010CD model. Pharmacological modulation of LXR\u03b2 may offer a novel therapeutic strategy for restoring neural circuit stability in FCD, highlighting its potential as a molecular target for intervention in drug\u2010resistant epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70671","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:30:18Z","timestamp":1764221418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver X Receptor Beta Regulates Glial Dynamics and Cortical Network Remodeling in a Freezing Lesion\u2013Cortical Dysplasia Model"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2392-5860","authenticated-orcid":false,"given":"Zhi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery General Hospital of Western Theater Command  Chengdu 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