{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:44Z","timestamp":1791330944700,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the effect of direct application of basic fibroblast growth factor (\n bFGF<\/jats:styled-content>\n ) on healing of tympanic membrane perforations due to direct traumatic penetration through the external auditory canal.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A prospective non\u2010blinded controlled study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University\u2010affiliated teaching hospital.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n In total, 104 patients with small [<25%] penetrating perforations were recruited. They were alternatively allocated to two groups: Control (spontaneous healing,\n n<\/jats:italic>\n \u00a0=\u00a051) and FGF treatment (direct application of\n bFGF<\/jats:styled-content>\n drops in the clinic and repeated daily by the patient,\n n<\/jats:italic>\n \u00a0=\u00a053).\n <\/jats:p>\n <\/jats:sec>\n \n Outcomes<\/jats:title>\n Perforation closure rate and time and hearing gain were recorded and compared between the two groups. Information on earache, dizziness and facial paralysis was also collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 93 (89%) patients were finally analysed. The closure rate at 3\u00a0m of the perforations in the control spontaneous healing and\n bFGF<\/jats:styled-content>\n treatment groups were 77% and 100%, respectively; the difference was statistically significant (\n P<\/jats:italic>\n \u00a0=\u00a00.01). The average closure time was 43.1\u00a0\u00b1\u00a02.5\u00a0days (range, 17\u201357\u00a0days) for control patients, which was significantly longer (\n P<\/jats:italic>\n \u00a0<\u00a00.01) than that for the\n bFGF<\/jats:styled-content>\n \u2010treated patients (12.6\u00a0\u00b1\u00a01.2\u00a0days; range, 3\u201321\u00a0days). The mean hearing improvement at 3\u00a0m was not significantly different between the FGF treatment and control groups (1.7\u00a0\u00b1\u00a02.4\n dB<\/jats:styled-content>\n vs 11.5\u00a0\u00b1\u00a01.9\n dB<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u00a0>\u00a00.05). No significant difference was observed in earache, dizziness and facial paralysis between two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Direct application of\n bFGF<\/jats:styled-content>\n may offer an effective topical management of penetrating traumatic tympanic membrane perforations, particularly for small\u2010sized perforations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.12017","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T10:03:07Z","timestamp":1347444187000},"page":"446-451","source":"Crossref","is-referenced-by-count":28,"title":["Impact of basic fibroblast growth factor on healing of tympanic membrane perforations due to direct penetrating trauma: a prospective non\u2010blinded\/controlled study"],"prefix":"10.1111","volume":"37","author":[{"given":"Q.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Yiwu Hospital of Traditional Chinese Medicine Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Wenzhou Medical College\u2010Affiliated Yiwu Central Hospital Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02387.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01764.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1097\/TA.0b013e318160773e","article-title":"Tympanic membrane perforation and hearing loss from blast overpressure in operation enduring freedom and operation Iraqi freedom wounded","volume":"64","author":"Ritenour A.E.","year":"2008","journal-title":"J. Trauma Injury Infect. Crit. Care."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608501111"},{"key":"e_1_2_7_6_1","first-page":"427","article-title":"Simple manoeuvre for closing traumatic eardrum perforation by micropore strip tape patching","volume":"11","author":"Saito H.","year":"1990","journal-title":"Am. J. Otol."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.03.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(82)90074-X"},{"key":"e_1_2_7_9_1","first-page":"757","article-title":"Otologic surgery following ear trauma","volume":"137","author":"Matthew Conoyer J.","year":"2007","journal-title":"Otolaryngol. 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North Am."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811409836"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181c34f01"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31822e0e53"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90008-A"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb49042.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0378-4274(92)90205-X","article-title":"Experience with the preclinical assessment of basic fibroblast growth factor (bFGF)","volume":"64","author":"Mazue\u2032 G.","year":"1992","journal-title":"Toxicol. Lett."}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:36:37Z","timestamp":1698748597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/coa.12017"],"URL":"https:\/\/doi.org\/10.1111\/coa.12017","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717968095.793467835","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717968095.793474116","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}