{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:30:53Z","timestamp":1771461053988,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Due to relatively high <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose accumulation in the tonsillar region, the detection of occult tonsillar cancers by <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose positron emission tomography\/computerised tomography remains controversial. Therefore, we assessed the usefulness of quantitative tonsil <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose uptake in identifying occult tonsillar squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A case\u2013control study of retrospective cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>eaching <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>We assessed all patients diagnosed with tonsillar cancers or cervical lymph node metastasis of unknown primary tumours between 2005 and 2010 who underwent <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose positron emission tomography\/computerised tomography. The subjects were grouped into <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (apparent early <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>\u2010stage tonsillar squamous cell carcinoma; <jats:italic>n<\/jats:italic>\u00a0=\u00a027), <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (occult tonsillar squamous cell carcinoma, primary tumours were found by surgery; <jats:italic>n<\/jats:italic>\u00a0=\u00a021), <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (cervical metastasis of unknown primary tumour, primary tumours were not found by surgery and for follow\u2010up; <jats:italic>n<\/jats:italic>\u00a0=\u00a016) and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (33 healthy controls). Tonsillar maximum standardised uptake values were bilaterally measured and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitivity and specificity of qualitative assessment of <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u2010fluorodeoxyglucose positron emission tomography\/computerised tomography for detection of occult tonsillar cancers were 67% and 69%, respectively. Mean maximum standardised uptake values of tonsils with cancer were 11.19\u00a0\u00b1\u00a05.46 in group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and 8.12\u00a0\u00b1\u00a04.52 in group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, which were significantly higher than that of group <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (4.62\u00a0\u00b1\u00a01.76) or group <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (4.57\u00a0\u00b1\u00a01.62) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). The mean maximum standardised uptake value differences of groups <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (6.35) and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (3.11) were significantly greater than those of groups <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (0.32) and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (0.59) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Similarly, the mean maximum standardised uptake value ratios of groups <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (2.47) and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (1.73) were significantly greater than those of groups <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (1.06) and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (1.16) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\/computerised tomography with tonsil <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max measurement is useful to identify occult tonsillar squamous cell carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12055","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T14:56:50Z","timestamp":1353423410000},"page":"30-38","source":"Crossref","is-referenced-by-count":10,"title":["Utility of quantitative <sup>18<\/sup><scp>F<\/scp>\u2010fluorodeoxyglucose uptake measurement to identify occult tonsillar carcinoma in patients with cervical metastasis of unknown primary tumours: a retrospective case\u2013control study"],"prefix":"10.1111","volume":"38","author":[{"given":"H.J.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010L.","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010J.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Samsung Changwon Hospital, Sungkyunkwan University School of Medicine Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea"},{"name":"Biomedical Research Institute Korea Institute of Science and Technology Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.7.599"},{"key":"e_1_2_9_4_1","first-page":"1369","article-title":"A combined PET\/CT scanner for clinical oncology","volume":"41","author":"Beyer T.","year":"2000","journal-title":"J. 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