{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:14:54Z","timestamp":1783433694152,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and tolerability of two commonly used nasal douching products, low\u2010volume high\u2010pressure Sterimar\u2122 and high\u2010volume low\u2010pressure Sinus Rinse\u2122 following functional endoscopic sinus surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective randomised single\u2010blinded study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010one patients, undergoing functional endoscopic sinus surgery for chronic rhinosinusitis with and without polyps, were recruited for the study. The patients acted as their own comparators self\u2010administering each douche three times daily into one randomly allocated nostril for a period of 12\u00a0weeks following the surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome measure was a blinded objective endoscopic assessment of each operated side using a modified Lund\u2010Kennedy endoscopic assessment tool undertaken at 2, 4 and 12\u00a0weeks postoperatively. As secondary outcome measures, the patients were asked to express a preference between the two products based on perceived effectiveness and ease of use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the preoperative scores, there was a statistically significant improvement in the <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022 score at all three postoperative time points (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Compared with week 2, there was a statistically significant reduction in the modified Lund\u2010Kennedy endoscopic scores (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) for both Sterimar\u2122 and Sinus Rinse\u2122 at weeks 4 and 12. When comparing Sterimar\u2122 with SinuRinse\u2122, there was a statistically significant lower modified Lund\u2010Kennedy score at 2 and 4\u00a0weeks postoperatively for the side treated with Sinus Rinse\u2122 (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05), indicating a more favourable outcome. However, this difference was not apparent at 12\u00a0weeks postoperatively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.66). At all time points, patients perceived Sinus Rinse\u2122 to be more effective than Sterimar\u2122 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), but there was no significant difference in the patients' preference for either product (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010volume low\u2010pressure saline irrigation is recommended as an efficacious, easy to use and well\u2010tolerated adjunct to endoscopic sinonasal toilet in the early postoperative period following functional endoscopic sinus surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12132","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T16:23:15Z","timestamp":1369758195000},"page":"297-305","source":"Crossref","is-referenced-by-count":41,"title":["A prospective randomised single\u2010blinded clinical trial comparing the efficacy and tolerability of the nasal douching products Sterimar\u2122 and Sinus Rinse\u2122 following functional endoscopic sinus surgery"],"prefix":"10.1111","volume":"38","author":[{"given":"R.J.","family":"Salib","sequence":"first","affiliation":[{"name":"Academic unit of Clinical and Experimental Sciences Department of Otorhinolaryngology \u2013 Head and Neck Surgery University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Talpallikar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Royal Hampshire County Hospital Winchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Uppal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Khoo Teck Puat Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Auckland University Hospitals and Manukau SuperClinic Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1999.tb05031.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0030-6665(20)30225-5","article-title":"Advances in postoperative care following functional endoscopic sinus surgery","volume":"30","author":"Kuhn F.A.","year":"1997","journal-title":"Otolaryngol. 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