{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:25Z","timestamp":1788829405753,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the outcomes of patients with early stage glottic cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) treated with radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, setting and participants<\/jats:title><jats:p>The current study report on a retrospective analysis of oncologic outcome of 1050 patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1\u20102<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>0 glottic cancer treated with radiotherapy. Prospective assessment of quality of life (<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) and voice handicap index (<jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>) was performed in all patients treated from 2006 onwards (<jats:italic>n<\/jats:italic>\u00a0=\u00a0233).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Local control (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>), regional control (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>), disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>), overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>), quality of life and voice handicap index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up of 90\u00a0months (range 3\u2013309), the actuarial rates of local control, regional control, disease\u2010free survival and overall survival were 85%, 99%, 84% and 81% at 5\u00a0years and 82%, 98%, 80% and 61% at 10\u00a0years, respectively. On multivariate analysis, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2 tumours, smoking after radiotherapy and conventional radiation scheme correlated significantly with poor local control. Patients who continued smoking after radiotherapy had also significantly lower overall survival rates (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Hypothyroidism was reported in 18% of patients. Slight and temporary deterioration of quality of life scores was reported. Patient\u2010reported xerostomia and dysphagia at 48\u00a0months were \u22127.1 and \u22126.5, compared with baseline, respectively. Voice handicap index improved significantly from 37 at baseline to 18 at 48\u00a0months. Patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2b and those who continued smoking had significantly worse voice handicap index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current study, excellent outcome with good quality of life and voice handicap index scores were reported. <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2 tumours, in particular <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2b, and continuing smoking after radiotherapy correlated significantly with poor local control and worse voice handicap index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12139","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T08:16:29Z","timestamp":1370333789000},"page":"306-312","source":"Crossref","is-referenced-by-count":79,"title":["Radiotherapy for <scp>T<\/scp>1\u20102<scp>N<\/scp>0 glottic cancer: a multivariate analysis of predictive factors 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