{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:11:39Z","timestamp":1696482699330},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the impact of unilateral vocal fold mobility impairment (<jats:styled-content style=\"fixed-case\">UVFMI<\/jats:styled-content>) on airway physiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Cross\u2010sectional observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>There were 21 patients with <jats:styled-content style=\"fixed-case\">UVFMI<\/jats:styled-content> and 53 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>All patients and patient controls underwent a maximum\u2010effort flow\u2010volume loop examination. Forced expiratory flow in one second (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>), forced expiratory volume (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>), peak inspiratory flow rate and peak expiratory flow rate (<jats:styled-content style=\"fixed-case\">PIFR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PEFR<\/jats:styled-content>, respectively) and area under the inspiratory and expiratory flow\u2010volume loops (<jats:styled-content style=\"fixed-case\">AUC<jats:sub>I<\/jats:sub><\/jats:styled-content><jats:sub>nspiratory<\/jats:sub> and <jats:styled-content style=\"fixed-case\">AUC<jats:sub>E<\/jats:sub><\/jats:styled-content><jats:sub>xpiratory,<\/jats:sub> respectively) were measured. The ratio of <jats:styled-content style=\"fixed-case\">PEFR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PIFR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AUC<jats:sub>E<\/jats:sub><\/jats:styled-content><jats:sub>xpiratory<\/jats:sub> to <jats:styled-content style=\"fixed-case\">AUC<jats:sub>I<\/jats:sub><\/jats:styled-content><jats:sub>nspiratory<\/jats:sub> was derived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 48 males and 26 females. Mean age at measurement was 39\u00a0\u00b1\u00a011\u00a0years. Patients and controls were matched for age, sex, height and weight. None of the expiratory variables were significantly different between the groups. <jats:styled-content style=\"fixed-case\">PIFR<\/jats:styled-content> was significantly lower in <jats:styled-content style=\"fixed-case\">UVFMI<\/jats:styled-content> patients compared with controls (3.4\u00a0\u00b1\u00a01.2 <jats:italic>versus<\/jats:italic> 5.3\u00a0\u00b1\u00a01.8; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), as was <jats:styled-content style=\"fixed-case\">AUC<jats:sub>I<\/jats:sub><\/jats:styled-content><jats:sub>nspiratory<\/jats:sub> (11.5\u00a0\u00b1\u00a06.3 <jats:italic>versus<\/jats:italic> 17.5\u00a0\u00b1\u00a08.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002). <jats:styled-content style=\"fixed-case\">PEFR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PIFR<\/jats:styled-content> provided the best differentiation between patients with <jats:styled-content style=\"fixed-case\">UVFMI<\/jats:styled-content> and controls with an area under the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eceiver <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>perating <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>haracteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve of 0.96 and at a threshold of 1.9, and <jats:styled-content style=\"fixed-case\">PEFR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PIFR<\/jats:styled-content> had sensitivity and specificity of 95.2% and 90.6%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Flow\u2010volume loops are a non\u2010invasive method of studying vocal abduction and could compliment voice assessment and laryngoscopy in <jats:styled-content style=\"fixed-case\">UVFMI<\/jats:styled-content>. With further research, they could provide an outcome measure for laryngeal rehabilitative procedures, and a shared physiological language for screening and surgical quality assurance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12259","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T11:52:41Z","timestamp":1400932361000},"page":"210-215","source":"Crossref","is-referenced-by-count":5,"title":["Impact of unilateral vocal fold mobility impairment on laryngopulmonary physiology"],"prefix":"10.1111","volume":"39","author":[{"given":"S.A.R.","family":"Nouraei","sequence":"first","affiliation":[{"name":"The National Centre for Airway Reconstruction Charing Cross Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Whitcroft","sequence":"additional","affiliation":[{"name":"The Royal National Throat Nose and Ear Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Patel","sequence":"additional","affiliation":[{"name":"The Royal National Throat Nose and Ear Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chatrath","sequence":"additional","affiliation":[{"name":"The National Centre for Airway Reconstruction Charing Cross Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.S.","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery Queen's Hospital Romford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kaddour","sequence":"additional","affiliation":[{"name":"The National Centre for Airway Reconstruction Charing Cross Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The Comparative Anatomy and Physiology of the Larynx","author":"Negus V.E.","year":"1949"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32504-2_4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32504-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.3.773"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.3.780"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.1.33"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201204"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23719"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180310574"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878708"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486509126989"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00115.x"},{"key":"e_1_2_9_15_1","first-page":"239","article-title":"The resistance and the Bernoulli effect of the glottis","volume":"5","author":"Berg J.","year":"1956","journal-title":"Acta. Physiol. Pharmacol. Neerl."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23176"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199903000-00015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.33.1.57"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1980.90.6.1027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611501103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32504-2_21"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588414X13814021676594"},{"key":"e_1_2_9_23_1","volume-title":"The British Association of Endocrine and Thyroid Surgeons: Fourth National Audit Report","author":"Chadwick D.","year":"2012"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:40:32Z","timestamp":1696390832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/coa.12259"],"URL":"https:\/\/doi.org\/10.1111\/coa.12259","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}