{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:03:09Z","timestamp":1767916989828,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,23]],"date-time":"2014-11-23T00:00:00Z","timestamp":1416700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"crossref","award":["TCVGH-1017004C"],"award-info":[{"award-number":["TCVGH-1017004C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the laryngopharyngeal reflux (LPR) episodes and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> values in patients with suspected obstructive sleep apnoea (OSA) using the Dx\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> oropharyngeal probe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Forty patients with complaint of snoring or suspected <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> were prospectively enrolled to receive full nocturnal polysomnography (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>). The patients were divided into 2 groups: a simple snorers group if the Respiratory Disturbance Index (<jats:styled-content style=\"fixed-case\">RDI<\/jats:styled-content>) was &lt; 5 and an <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> group if the <jats:styled-content style=\"fixed-case\">RDI<\/jats:styled-content> was \u2265 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The patients simultaneously received Dx\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> oropharyngeal probe monitoring for 12\u00a0h from about 6\u00a0pm to 6 am of the next day. The number of LPR events was recorded if the nadir of rapid <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> drops was below <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 5.0 and 5.5. The difference of LPR events between the two groups and the difference of LPR events between awake and sleep periods in each group were analysed, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 18 (45%) patients diagnosed as OSA with a mean RDI of 28.7, and 22 patients (55%) diagnosed as simple snorers. Between 2 groups, there were no significant differences in the LPR events and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> values during the awake period, sleep period or overall recording period. Comparison of the LPR events and minimum <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> values between the awake period and the sleep period revealed there were no significant differences in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using the new sensitive Dx\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> oropharyngeal probe with PSG, we found that OSA does not correlate with a higher incidence of LPR episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12297","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T20:23:09Z","timestamp":1407961389000},"page":"352-358","source":"Crossref","is-referenced-by-count":5,"title":["Airway <scp>pH<\/scp> monitoring in patients with suspected obstructive sleep apnoea using the Dx\u2010<scp>pH<\/scp> oropharyngeal probe: preliminary report of a prospective cohort study"],"prefix":"10.1111","volume":"39","author":[{"given":"C.\u2010C.","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"School of Speech Language Pathology &amp; Audiology Chung\u2010Shan Medical University Taichung Taiwan"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010C.","family":"Lien","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Gastroenterology Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Public Health China Medical University and Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Virgilio","sequence":"additional","affiliation":[{"name":"Department of Sensory Organs ENT section Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Respiratory and Critical Care Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Life Sciences National Chung\u2010Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010F.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology Central Taiwan University of Science and Technology Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010A.","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010P.","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Speech Language Pathology &amp; Audiology Chung\u2010Shan Medical University Taichung Taiwan"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010L.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"},{"name":"School of Medicine Chung\u2010Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.\u2010S.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"},{"name":"School of Medicine Chung\u2010Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.155"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_10_5_1","first-page":"533","article-title":"Snoring and sleep apnea in men: association with central obesity and hypertension","volume":"17","author":"Grunstein R.","year":"1993","journal-title":"Int. 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