{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:11:33Z","timestamp":1784693493896,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Background<\/jats:title>Incidence rates of M<\/jats:styled-content>eniere's syndrome\/disease vary considerably from 157 per 100\u00a0000 in the U<\/jats:styled-content>nited K<\/jats:styled-content>ingdom to 15 per 100\u00a0000 in the U<\/jats:styled-content>nited S<\/jats:styled-content>tates. A wide range of treatments are used for the treatment of the condition with no consensus on the most effective intervention.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To assess the effectiveness of the M<\/jats:styled-content>eniett device in reducing the frequency and severity of vertigo in M<\/jats:styled-content>eniere's syndrome\/disease.<\/jats:p><\/jats:sec>Search methods<\/jats:title>The C<\/jats:styled-content>ochrane E<\/jats:styled-content>ar, N<\/jats:styled-content>ose and T<\/jats:styled-content>hroat D<\/jats:styled-content>isorders G<\/jats:styled-content>roup T<\/jats:styled-content>rials R<\/jats:styled-content>egister; the C<\/jats:styled-content>ochrane C<\/jats:styled-content>entral R<\/jats:styled-content>egister of C<\/jats:styled-content>ontrolled T<\/jats:styled-content>rials (CENTRAL<\/jats:styled-content>); P<\/jats:styled-content>ubM<\/jats:styled-content>ed; EMBASE<\/jats:styled-content>; CINAHL<\/jats:styled-content>; W<\/jats:styled-content>eb of S<\/jats:styled-content>cience; BIOSIS P<\/jats:styled-content>reviews; C<\/jats:styled-content>ambridge S<\/jats:styled-content>cientific abstracts; ICTRP<\/jats:styled-content> and additional sources for published and unpublished trials were searched. The date of the last search was 13th M<\/jats:styled-content>ay 2014.<\/jats:p><\/jats:sec>Selection criteria<\/jats:title>Four randomised controlled trials (RCT<\/jats:styled-content>s) were identified that compared the efficacy of the M<\/jats:styled-content>eniett device versus a placebo device in patients with M<\/jats:styled-content>eniere's \u2018disease\u2019 as defined by the AAOO<\/jats:styled-content> criterion.<\/jats:p><\/jats:sec>Data collection and analysis<\/jats:title>Two review authors independently assessed study eligibility and risk of bias and extracted data. The outcome data were dichotomous for all the included trials.<\/jats:p><\/jats:sec>Main results<\/jats:title>The four RCT<\/jats:styled-content>s compared 123 patients with the M<\/jats:styled-content>eniett device against 114 patients with the placebo device from four RCT<\/jats:styled-content>'s over a follow\u2010up period of 2\u00a0weeks to 4\u00a0months. There was a significant overall 61% reduction in the frequency of vertigo in both groups (mean no vertigo days per month of 8\u20133). However, this reduction was not significantly different between the two groups in any study or on meta\u2010analysis [mean difference in vertigo\u2010free days between M<\/jats:styled-content>eniett and placebo device of 0.77\u00a0days over a 1\u2010month period (95% CI<\/jats:styled-content> \u2013 0.82, 1.83) P<\/jats:italic>\u00a0=\u00a00.45].<\/jats:p>There were also no substantive data to support a greater reduction in the severity of the vertigo or any other outcome with the M<\/jats:styled-content>eniett device compared with the placebo device.<\/jats:p><\/jats:sec>Authors conclusions<\/jats:title>No evidence was found to justify the use of the M<\/jats:styled-content>eniett device in M<\/jats:styled-content>eniere's syndrome\/disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12344","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T05:48:14Z","timestamp":1414129694000},"page":"197-207","source":"Crossref","is-referenced-by-count":19,"title":["Positive pressure therapy for M<\/scp>eniere's syndrome\/disease with a M<\/scp>eniett device: a systematic review of randomised controlled trials"],"prefix":"10.1111","volume":"40","author":[{"given":"M.I.","family":"Syed","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The Royal Infirmary Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Rutka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Toronto University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hendry","sequence":"additional","affiliation":[{"name":"Department of Surgery Glasgow Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.G.","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology MRC\/CSO Institute of Hearing Research Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"29","article-title":"Sur une forme de surdit\u00e9 grave d\u00e9pendant d'une l\u00e9sionde l'oreille interne","volume":"16","author":"M\u00e9ni\u00e8re P.","year":"1861","journal-title":"Gaz. 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