{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:06Z","timestamp":1778198406263,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the risk of peri\u2010operative bleeding and re\u2010intervention with peritonsillar lornoxicam infiltration in paediatric tonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, randomised, double\u2010blinded, placebo\u2010controlled, split\u2010body study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 68 patients (7\u201315\u00a0years), <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> I\u2013II, scheduled for tonsillectomy divided into two groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) to receive bilateral peritonsillar saline infiltration (placebo group) or peritonsillar saline infiltration in one tonsil (placebo side) and 8\u00a0mg lornoxicam in the other tonsil (intervention side; study group). Drugs were administered after induction of anaesthesia and before start of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Intra\u2010operative and postoperative bleeding score, platelet aggregometry before and 30\u00a0min after study drug administration, the verbal rating pain scale, time to first postoperative analgesic request, total analgesic consumption during 1st 24\u00a0h postoperative and adverse effects were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference in bleeding score between groups did not reach our definition of statistical significance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Platelet aggregometry tests did not change significantly with time between groups. Lower postoperative pain scores, longer time to first analgesic request (372.76\u00a0\u00b1\u00a082.15 <jats:italic>versus<\/jats:italic> 64.89\u00a0\u00b1\u00a025.76\u00a0min <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and lower paracetamol consumption (421.76\u00a0\u00b1\u00a0125.63 <jats:italic>versus<\/jats:italic> 690.29\u00a0\u00b1\u00a0141.47\u00a0mg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were recorded in study group compared with control group. No patient required hospital re\u2010admission or re\u2010operation because of postoperative tonsillar bed bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of significant complications suggests that pre\u2010incisional peritonsillar lornoxicam followed by intravenous paracetamol rescue analgesia may be safe for tonsillectomy in children. To avoid conflict with intra\u2010operative bleeding, postoperative infiltration of lornoxicam is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12351","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:14:42Z","timestamp":1416269682000},"page":"219-226","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED: Safety and efficacy of pre\u2010incisional peritonsillar lornoxicam in paediatric post\u2010tonsillectomy pain: a prospective double\u2010blind, placebo\u2010controlled, split\u2010body clinical study"],"prefix":"10.1111","volume":"40","author":[{"given":"H.S.","family":"Abdel\u2010Ghaffar","sequence":"first","affiliation":[{"name":"Anesthesia and Intensive Care Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.G.","family":"Abdel\u2010Azeem","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Roushdy","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael256"},{"key":"e_1_2_9_3_1","first-page":"CD003997","article-title":"Steroids for improving recovery following tonsillectomy in children","volume":"10","author":"Steward D.L.","year":"2011","journal-title":"Cochrane Database Syst. 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