{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:13:26Z","timestamp":1773173606372,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives\/hypothesis<\/jats:title><jats:p>Squamous cell carcinoma of the nasal vestibule (<jats:styled-content style=\"fixed-case\">SCCNV<\/jats:styled-content>) is a rare tumour entity. Treatment modality, particularly indication of neck dissection, is still a controversial subject of debate. We sought to evaluate the occurrence of lymph node metastases, the prognosis and the immunohistochemical characteristics of <jats:styled-content style=\"fixed-case\">SCCNV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 30 consecutive patients with <jats:styled-content style=\"fixed-case\">SCCNV<\/jats:styled-content> treated with primary tumour resection and neck dissection in cases of suspicious lymph nodes between 2003 and 2013. According to therapeutical standard adjuvant radiotherapy or chemotherapy were applied in some cases. Clinicopathological data and immunohistochemical expression of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6, <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>, Ki\u201067, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109, p53 and <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content> were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 47.1\u00a0months. Five\u2010year disease\u2010free (5\u2010year <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) and 5\u2010year overall survival (5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were 91.7% and 92.3%. Five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in low\u2010grade tumours (G1, G2) was 100.0%, in high\u2010grade tumours (G3) 75.0% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), respectively. We did not detect any lymph node metastases in the neck dissections. Overexpression of p53 showed a trend for better 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (p53\u2010positive 100% <jats:italic>versus<\/jats:italic> p53\u2010negative 77.8%, n.s.). We found a positive correlation between p53 and <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). There was no significant relationship between the expression rates of the markers and tumour stage and grading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose no prophylactic neck dissection in small\u2010sized <jats:styled-content style=\"fixed-case\">SCCNV<\/jats:styled-content>. Subtile endoscopic follow\u2010up and periodic ultrasound examination of the cervical lymph nodes after surgical treatment are recommended. Further evaluation of the p53\u2010 and <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\u2010pathways might pave the way to identify possible molecular targets in an attempt to tailor tumour management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12359","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T11:46:15Z","timestamp":1418730375000},"page":"240-247","source":"Crossref","is-referenced-by-count":22,"title":["Clinicopathological and immunohistochemical characteristics of surgically treated primary carcinoma of the nasal vestibule \u2013 an evaluation of 30 cases"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Koopmann","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Savvas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rudack","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stenner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90037-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.031"},{"key":"e_1_2_9_4_1","first-page":"117","article-title":"Squamous cell carcinoma of the nasal vestibule","volume":"37","author":"Horsmans J.D.","year":"1999","journal-title":"Rhinology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21570"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0503-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-009-0170-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002259"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.107450"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.04.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1740-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<100::AID-CNCR2820380118>3.0.CO;2-9"},{"key":"e_1_2_9_15_1","article-title":"Clinicopathological characteristics of carcinoma from unknown primary in cervical lymph nodes","author":"Weiss D.","year":"2014","journal-title":"Eur. 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