{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:13:32Z","timestamp":1772241212343,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the prognostic influence of hyoid bone invasion in advanced base of tongue squamous cell carcinoma treated with chemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed pre\u2010treatment imaging (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) for the presence or absence of hyoid bone invasion in patients with advanced (clinical T3 or T4a stage) base of tongue squamous cell carcinoma treated with chemoradiation from January 2001 to January 2011. We compared patients with hyoid bone invasion to those without based on the following metrics: 1\u2010, 2\u2010 and 5\u2010year locoregional recurrence\u2010free survival, disease\u2010free survival, disease\u2010specific survival and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven of thirty\u2010seven patients had hyoid invasion present on pre\u2010treatment imaging. Average follow\u2010up was 45\u00a0months.<\/jats:p><jats:p>Patients with hyoid bone invasion were found to have lower percentages in all survival metrics measured compared to patients without, respectively, with statistical significance achieved in the following: 2\u2010year locoregional recurrence\u2010free survival: 36.4% <jats:italic>versus<\/jats:italic> 86.4% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), 5\u2010year locoregional recurrence\u2010free survival: 12.5% <jats:italic>versus<\/jats:italic> 63.6% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), 2\u2010year disease\u2010free survival: 36.4% <jats:italic>versus<\/jats:italic> 77.3% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), 5\u2010year disease\u2010free survival: 12.5% <jats:italic>versus<\/jats:italic> 63.3% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and the Kaplan\u2013Meier curve for locoregional recurrence\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0075).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyoid bone invasion by base of tongue squamous cell carcinoma may indicate a poorer prognosis despite treatment. Hyoid bone invasion may be a possible indication for intensification of treatment and\/or may indicate a necessity for increasing the degree of post\u2010treatment surveillance monitoring and imaging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12367","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T09:54:58Z","timestamp":1420624498000},"page":"260-265","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic significance of hyoid bone invasion in advanced base of tongue carcinoma treated by chemoradiation"],"prefix":"10.1111","volume":"40","author":[{"given":"C.M.","family":"Heaton","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of California \u2013 San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Al\u2010Shwaiheen","sequence":"additional","affiliation":[{"name":"School of Medicine Graduate Program for Clinical Research University of California \u2013 San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010S.J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology Department of Radiology and Biomedical Imaging University of California \u2013 San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of California \u2013 San Francisco San Francisco CA USA"},{"name":"Department of Radiation Oncology University of California \u2013 San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic\/Endocrine\/Salivary Surgery Department of Otolaryngology \u2013 Head and Neck Surgery University of California \u2013 San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199205000-00008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.12.1451"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.11.016"},{"key":"e_1_2_9_7_1","unstructured":"Clinical practice guidelines in oncology: head and neck cancers National Comprehensive Cancer Network"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10069"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1994.tb01284.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200106000-00028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000166896.67924.B7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00415-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24712"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24748"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T07:32:57Z","timestamp":1758526377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/coa.12367"],"URL":"https:\/\/doi.org\/10.1111\/coa.12367","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}