{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:18:07Z","timestamp":1761059887261,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006109","name":"VEGA","doi-asserted-by":"crossref","award":["1\/0416\/12","APVV-0435-11"],"award-info":[{"award-number":["1\/0416\/12","APVV-0435-11"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The study was designed to determine whether there is an association between the comorbidity as atopy, bronchial asthma, aspirin intolerance and eosinophil infiltration of the upper airways, severity of the sinonasal disease and rate of revision sinus surgery in patients with nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>One hundred and fifty patients were enrolled in the prospective study. Differences in <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> score, rate of revision surgery, concentration of eotaxin and eosinophil cationic protein in nasal lavage fluid (<jats:styled-content style=\"fixed-case\">NALF<\/jats:styled-content>) and distribution of eosinophils in <jats:styled-content style=\"fixed-case\">NALF<\/jats:styled-content> and nasal tissue in patients with chronic rhinosinusitis with nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>), chronic rhinosinusitis without nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) and control group were investigated. We focused on the relationship between presence of comorbidity (atopy, bronchial asthma and aspirin intolerance) and severity of the disease, the need of revision surgery and markers of eosinophil inflammation in upper airways in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> had more severe form of the sinonasal disease, higher rate of revision <jats:styled-content style=\"fixed-case\">FESS<\/jats:styled-content> and significant higher presence of markers of eosinophil inflammation in <jats:styled-content style=\"fixed-case\">NALF<\/jats:styled-content> and nasal tissue than patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Atopic and non\u2010atopic asthma as well\u00a0as aspirin sensitivity significantly more often coexisted with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>. Comorbidity did not influence eosinophil infiltration or severity of the disease in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presence of comorbidity (atopy, bronchial asthma and aspirin intolerance) has no impact on severity of the disease or eosinophil content in the upper airways in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12392","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T11:49:28Z","timestamp":1424087368000},"page":"429-436","source":"Crossref","is-referenced-by-count":11,"title":["Comorbidity has no impact on eosinophil inflammation in the upper airways or on severity of the sinonasal disease in patients with nasal polyps"],"prefix":"10.1111","volume":"40","author":[{"given":"B.","family":"Uhliarova","sequence":"first","affiliation":[{"name":"Department of Physiology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia"},{"name":"Department of Otorhinolaryngology FD Roosevelt Faculty Hospital Banska Bystrica Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kopincova","sequence":"additional","affiliation":[{"name":"Department of Physiology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kolomaznik","sequence":"additional","affiliation":[{"name":"Department of Physiology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Adamkov","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Svec","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology FD Roosevelt Faculty Hospital Banska Bystrica Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Calkovska","sequence":"additional","affiliation":[{"name":"Department of Physiology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"3","author":"Fokkens W.J.","year":"2012","journal-title":"Rhinol. 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