{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:35:48Z","timestamp":1770442548313,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate the risk of peripheral arterial occlusive disease (<jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content>) in patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) using a nationwide claim database in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A population\u2010based case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Data from the Longitudinal Health Insurance Database 2000 of the Taiwan's National Health Insurance Research Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eleven thousand eight hundred and seventeen adult patients diagnosed with <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> between January 1, 2001 and December 31, 2010 and 35\u00a0451 controls without <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> frequency matched by sex, 10\u2010year age interval and year of index date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Obstructive sleep apnoea and a number of comorbidities prior to the index date were assessed and analysed with logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate logistic regression analysis showed that <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> was significantly associated with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> (odds ratio, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.60, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Multivariate logistic regression analysis, adjusted for coronary artery disease or myocardial infarction, chronic kidney disease, hyperurecaemia and obesity, also showed that <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> was significantly associated with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.37, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014). However, the association was attenuated when it was further adjusted for hypertension, hyperlipidaemia and diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings from this nationwide population\u2010based study indicated that <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> was significantly associated with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>. Further studies are warranted to determine whether <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> may contribute to the development of <jats:styled-content style=\"fixed-case\">PAOD<\/jats:styled-content> indirectly via increasing the risks of hypertension, hyperlipidaemia and\/or <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12393","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T10:48:35Z","timestamp":1424342915000},"page":"437-442","source":"Crossref","is-referenced-by-count":17,"title":["Risks of peripheral arterial occlusive disease in patients with obstructive sleep apnoea: a population\u2010based case\u2013control study"],"prefix":"10.1111","volume":"40","author":[{"given":"J.\u2010C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Department of Otolaryngology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"},{"name":"Sleep Center Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja13.10579"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810390859"},{"key":"e_1_2_10_5_1","first-page":"43","article-title":"Eye diseases in patients with sleep apnea syndrome: a review","volume":"312","author":"Groot V.","year":"2009","journal-title":"Bull. 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