{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:12Z","timestamp":1787014032738,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content>\n                      classification system for squamous cell carcinoma (\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      ) of the head and neck neglects to incorporate volumetric analysis of the primary tumour. Tumour volume (\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      ) has been implicated prognostically in laryngeal\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      treated by primary radiotherapy (\n                      <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                      ), but data for patients treated surgically are lacking. We evaluated such for glottic\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      s resected by transoral laser microsurgery (\n                      <jats:styled-content style=\"fixed-case\">TLM<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Retrospective cohort study utilising\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      s calculated as the product of tumour resection dimensions and time\u2010to\u2010event analyses using the Kaplan\u2013Meier method. The prognostic ability of variables was estimated using log\u2010rank statistics, univariate Cox regression and receiver\u2010operating characteristics analysis where appropriate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral head and neck cancer centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Patients undergoing primary\n                      <jats:styled-content style=\"fixed-case\">TLM<\/jats:styled-content>\n                      for glottic\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      with curative intent (2007\u20132011) with at least 12\u00a0months follow\u2010up data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      Prognostic impact of\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      on local control (\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      ), overall survival (\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      ) and disease\u2010specific survival (\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eligible patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0129) had a median follow\u2010up of 40\u00a0months (range 14\u201379\u00a0months). Median\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      for all cases was 300\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      (range 2\u201319800\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      ). Three\u2010year\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      were 92%, 92% and 98%, respectively. Tumour volume was not a significant predictor of any oncological outcome measure. Otherwise, a significant influence of pT stage on\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      was observed and of age on\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In contrast to laryngeal\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      treated by\n                      <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      does not appear to portend oncological outcome in glottic\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      managed specifically by\n                      <jats:styled-content style=\"fixed-case\">TLM<\/jats:styled-content>\n                      and consequently does not warrant incorporation into current prognostic models for such patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.12421","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T07:23:46Z","timestamp":1427268226000},"page":"610-615","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic implications of pathologically determined tumour volume in glottic carcinomas treated by transoral laser microsurgery"],"prefix":"10.1111","volume":"40","author":[{"given":"M.D.","family":"Wilkie","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital Aintree Liverpool UK"},{"name":"Liverpool Cancer Research Centre Department of Molecular &amp; Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Lightbody","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital Aintree Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pinto","sequence":"additional","affiliation":[{"name":"School of Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital Aintree Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital Aintree Liverpool UK"},{"name":"Liverpool Cancer Research Centre Department of Molecular &amp; Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital Aintree Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21361"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_8_5_1","volume-title":"International Union Against Cancer. 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