{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:33:53Z","timestamp":1773405233027,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Meniere's syndrome or disease (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/D) is typically characterised by episodic vertigo, aural fullness, tinnitus and fluctuating hearing loss. There are multiple options available for treatment with variation in consensus on the best intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the evidence on the efficacy of intratympanic therapies [steroids, gentamicin, antivirals and other therapies] on the frequency and severity of vertigo and other symptoms of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>A literature search was performed on <jats:styled-content style=\"fixed-case\">AMED<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HMIC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MEDLINE<\/jats:styled-content>, Psyc<jats:styled-content style=\"fixed-case\">INFO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BNI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CINAHL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HEALTH BUSINESS ELITE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content> and Cochrane Ear, Nose and Throat disorders group trials register using various Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>. The search was restricted to English and human subjects, and the last date of search was December 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomised controlled trials of intratympanic therapies [steroids, gentamicin antivirals and latanoprost] <jats:italic>versus<\/jats:italic> a placebo or another treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed 8 <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>'s comparing intratympanic steroids, gentamicin, ganciclovir (antiviral) and latanoprost <jats:italic>versus<\/jats:italic> another form of intratympanic treatment or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On the basis of 6 <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>'s (<jats:italic>n\u00a0<\/jats:italic>=\u00a0242), there is evidence to support the effectiveness of intratympanic steroids and gentamicin to control symptoms of vertigo in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/D albeit with a risk of hearing loss with gentamicin. However, there was no consensus found on doses or treatment protocols. There was no evidence to support the use of other forms of intratympanic therapy (antivirals and latanoprost) in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12449","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T14:26:59Z","timestamp":1430144819000},"page":"682-690","source":"Crossref","is-referenced-by-count":35,"title":["Intratympanic therapy in Meniere's syndrome or disease: up to date evidence for clinical practice"],"prefix":"10.1111","volume":"40","author":[{"given":"M.I.","family":"Syed","sequence":"first","affiliation":[{"name":"Otology &amp; Skull base surgery The Royal Infirmary of Edinburgh Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ilan","sequence":"additional","affiliation":[{"name":"Otology\/Neurotology University Health Network Toronto ON Canada M5G 2C4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nassar","sequence":"additional","affiliation":[{"name":"Otology\/Neurotology University Health Network Toronto ON Canada M5G 2C4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Rutka","sequence":"additional","affiliation":[{"name":"Otology\/Neurotology University Health Network Toronto ON Canada M5G 2C4"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"29","article-title":"Sur une forme de surdit\u00e9 grave d\u00e9pendant d'une l\u00e9sionde l'oreille interne","volume":"16","author":"M\u00e9ni\u00e8re P.","year":"1861","journal-title":"Gaz M\u00e9d de Paris"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. 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