{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:34:56Z","timestamp":1760985296674,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this<jats:italic>pilot<\/jats:italic>economic evaluation was to assess the cost\u2010effectiveness of the endoscopic polypectomy in the clinic (<jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>) procedure compared to formal endoscopic sinus surgery (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) for the treatment of select chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) patients with nasal polyposis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cost\u2010effectiveness analysis using a<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arkov decision tree model with a 30\u2010year time horizon. The two comparative treatment groups were as follows: (i)<jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>and (ii)<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>. Costs and effects were discounted at a rate of 3.5%. A probabilistic sensitivity analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Economic perspective of the<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anadian government third\u2010party payer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>patients with nasal polyposis who have predominantly isolated symptoms of nasal obstruction with or without olfactory loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incremental cost per quality adjusted life year (<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a time period of 30\u00a0years, the reference case demonstrated that the<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>strategy cost a total of $21\u00a0345 and produced 13.17<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s while the<jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>strategy cost a total of $5591 and produced 12.93<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s. The<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content><jats:italic>versus<\/jats:italic><jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>incremental cost\u2010effectiveness ratio was $65\u00a0641\/<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>. The probability that<jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>is cost\u2010effective compared to<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>at a maximum willingness\u2010to\u2010pay threshold of $30\u00a0000 and $50\u00a0000\/<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>is 66% and 60%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Outcomes from this study have demonstrated that the<jats:styled-content style=\"fixed-case\">EPIC<\/jats:styled-content>procedure may be a cost\u2010effective treatment strategy for \u2018select\u2019 patients with nasal polyposis. 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