{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:45:32Z","timestamp":1695811532811},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to evaluate patients with otosclerosis with respect to bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) at different regions of interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>), using dual\u2010energy X\u2010ray absorptiometry (<jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The patients with a definite diagnosis of otosclerosis confirmed intra\u2010operatively were defined as the study group (<jats:italic>n<\/jats:italic>\u00a0=\u00a030). The control group consisted of volunteer, healthy subjects with normal hearing (<jats:italic>n<\/jats:italic>\u00a0=\u00a043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Following an audiometric evaluation, a venous blood sample was obtained and a single <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> measurement using <jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content> was applied to each participant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>,<jats:italic> T<\/jats:italic> and <jats:italic>Z<\/jats:italic> scores were higher in the otosclerosis group than in the control group in all the regions considered, but not significantly; only the L2\u2010L3 lateral <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and its <jats:italic>T<\/jats:italic> and <jats:italic>Z<\/jats:italic> scores were significant (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.036, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.036, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that the <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> does not decrease in the presence of otosclerosis despite its genetic and metabolic relevance with osteoporosis. Concerning the L2\u2010L3 lateral <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> measurements, the <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> increased in otosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12486","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T13:38:57Z","timestamp":1434807537000},"page":"149-153","source":"Crossref","is-referenced-by-count":1,"title":["Bone mineral density measurements in otosclerosis using dual\u2010energy X\u2010ray absorptiometry"],"prefix":"10.1111","volume":"41","author":[{"given":"S.B.","family":"Tonuk","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Medical Faculty Abant Izzet Baysal University Golkoy Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Koybasi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Medical Faculty Abant Izzet Baysal University Golkoy Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.O.","family":"Bicer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Medical Faculty Abant Izzet Baysal University Golkoy Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Alkan Temel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Medical Faculty Abant Izzet Baysal University Golkoy Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813509951"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2003.00675.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0967-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000204142.80263.2b"},{"key":"e_1_2_8_7_1","first-page":"172","article-title":"Bone metabolism in children and adolescents: main characteristics of the determinants of peak bone mass","volume":"10","author":"Stagi S.","year":"2013","journal-title":"Clin. 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