{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:27:08Z","timestamp":1770514028094,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Calcium alginate is a biodegradable gel\u2010transforming agent widely used for nasal packing. It can reduce pain and improve comfort. However, few randomised controlled trials have compared the efficacy of calcium alginate nasal packing with that of other biodegradable gel\u2010transforming materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, randomised, single\u2010blinded controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Yonsei University Severance Hospital, a tertiary academic medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Twenty\u2010seven patients (54 nostrils) with chronic rhinosinusitis who were scheduled for bilateral endoscopic sinus surgery were enrolled. After surgery, one nostril was packed with calcium alginate and the other with carboxymethyl cellulose. Only patients with an intersinus chronic rhinosinusitis severity score difference of \u22641 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) scores for postoperative pain, discomfort from nasal discharge and pain during packing removal were analysed. Two independent rhinologists who were blinded to the assessments separately scored adhesions, oedema and infection by endoscopic digital photography at 1, 4 and 8 weeks postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores for postoperative pain, discomfort from nasal discharge or pain during packing removal between calcium alginate packings and carboxymethyl cellulose packings. Inter\u2010rater variability of adhesion, oedema and infection scores was acceptable. Adhesion severity and oedema scores at 4 weeks were significantly lower with calcium alginate packing than with carboxymethyl cellulose. Infection severity scores also tended to be lower with calcium alginate than with carboxymethyl cellulose, but the difference was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Calcium alginate nasal packing is associated with reduced severity of oedema and adhesions after endoscopic sinus surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12505","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T16:17:05Z","timestamp":1437754625000},"page":"234-240","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single\u2010blinded trial"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-3051","authenticated-orcid":false,"given":"D.\u2010Y.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cheonan Hospital Soonchunhyang University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.S.","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.H.","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"},{"name":"The Airway Mucus Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"},{"name":"The Airway Mucus Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199409000-00006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21446"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000230399.24306.50"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.04.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0841-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3600"},{"key":"e_1_2_9_8_1","first-page":"41","article-title":"Evaluation of Surgicel Nu\u2010knit, Merocel and Vasolene gauze nasal packs: a randomized trial","volume":"34","author":"Shinkwin C.A.","year":"1996","journal-title":"Rhinology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1992.tb01834.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12117"},{"key":"e_1_2_9_11_1","first-page":"58","article-title":"Evaluation of calcium alginate nasal packing (Algost\u00e9ril\u00ae) versus polyvinyl acetal (Merocel\u00ae) for nasal packing after inferior turbinate resection","volume":"44","author":"Chevillard C.","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.02.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100111004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300460-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(83)90036-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.09.012"},{"key":"e_1_2_9_17_1","first-page":"78","article-title":"Packing materials for nasal and paranasal sinus","volume":"17","author":"Park D.J.","year":"2010","journal-title":"J. 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