{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:42:56Z","timestamp":1788248576620,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"\n Background<\/jats:title>\n \n Robin Sequence (\n RS<\/jats:styled-content>\n ) is usually defined as the combination of micrognathia, glossoptosis and upper airway obstruction. No objective criteria to diagnose\n RS<\/jats:styled-content>\n exist. To compare management strategy results, a single\n RS<\/jats:styled-content>\n definition using objective criteria is needed. The most frequently used primary diagnostic tool for glossoptosis is awake Flexible Fiberoptic Laryngoscopy (\n aFFL<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To determine the reliability of the\n aFFL<\/jats:styled-content>\n videos as an independent diagnostic tool itself, rather than on the complete evaluation of a patient.\n <\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants<\/jats:title>\n \n All\n RS<\/jats:styled-content>\n individuals from an existing cohort with an available\n aFFL<\/jats:styled-content>\n video were included retrospectively. Thirty age\u2010matched patients without pathologic findings on\n aFFL<\/jats:styled-content>\n were used as controls.\n aFFL<\/jats:styled-content>\n videos were scored by six otolaryngologists as: a. Marked glossoptosis, b. Mild glossoptosis, c. Severity unknown, d. No glossoptosis, e. Insufficient video quality. Videos were anonymised and rated twice, in altered sequences, after a washout period of minimally 2 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Inter\u2010rater and intrarater agreement.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010six videos of 16\n RS<\/jats:styled-content>\n patients and 30 videos of controls were included. Inter\u2010rater agreement was fair in the whole group (\n \u03ba<\/jats:italic>\n : 0.320) and\n RS<\/jats:styled-content>\n group (\n \u03ba<\/jats:italic>\n : 0.226), and fair to moderate in determining presence of glossoptosis (total group\n \u03ba<\/jats:italic>\n : 0.430;\n RS<\/jats:styled-content>\n \u03ba<\/jats:italic>\n : 0.302; controls\n \u03ba<\/jats:italic>\n : 0.212). The intrarater agreement for the presence of glossoptosis in\n RS<\/jats:styled-content>\n was moderate (\n \u03ba<\/jats:italic>\n : 0.541).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n aFFL<\/jats:styled-content>\n offers fair to moderate inter\u2010rater agreement, with moderate intrarater agreement, in evaluating glossoptosis in\n RS<\/jats:styled-content>\n . Using\n aFFL<\/jats:styled-content>\n as the single tool in choosing management strategies in\n RS<\/jats:styled-content>\n seems insufficient. There is need for a more reliable, patient friendly diagnostic tool or an internationally accepted\n aFFL<\/jats:styled-content>\n scoring system, to diagnose glossoptosis in RS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.12552","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T03:12:42Z","timestamp":1444014762000},"page":"467-471","source":"Crossref","is-referenced-by-count":7,"title":["Awake Flexible Fiberoptic Laryngoscopy to diagnose glossoptosis in Robin Sequence patients"],"prefix":"10.1111","volume":"41","author":[{"given":"H.","family":"Basart","sequence":"first","affiliation":[{"name":"Department of Pediatrics Academic Medical Center\/Emma Pediatric Hospital Amsterdam Netherlands"},{"name":"Department of Plastic, Reconstructive and Hand Surgery Academic Medical Center University of Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Academic Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Bretschneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology VU Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.L.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Academic Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.P.Q.","family":"Oomen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Utrecht Medical Center\/Wilhelmina Children's Hospital Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pullens","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Erasmus Medical Center\/Sophia Pediatric Hospital Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.N.P.M.","family":"Rinkel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology VU Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.D.L.","family":"van Gogh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology VU Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.A.M.","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery Academic Medical Center University of Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Hennekam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Academic Medical Center\/Emma Pediatric Hospital Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-061.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.10.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.3.389"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37154"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182074799"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2615"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22054"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.08.045"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118032923"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.11.042"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200206000-00009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.09.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.1067"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(86)80008-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-011-2147-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.6.1069"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17100790"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2231011023"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2271020198"}],"container-title":["Clinical 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