{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:41Z","timestamp":1791822341809,"version":"4.3.4"},"reference-count":94,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Honey and beehive products were rediscovered as an alternative treatment in wounds. The medicinal properties also raised interest of their use in Otorhinolaryngology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective of review<\/jats:title><jats:p>To give an overview of the effectiveness of beehive products in Otorhinolaryngology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Type of review<\/jats:title><jats:p>Narrative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy and evaluation<\/jats:title><jats:p>A literature search of the databases PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and Cochrane was performed from the last two decades till December 2014. The search terms \u2018honey\u2019, \u2018propolis\u2019 or \u2018royal jelly\u2019 were used. Articles, which evaluated the effectiveness of beehive products in Otorhinolaryngology, were included. The quality assessment of included studies was performed using the Cochrane Collaboration's risk of bias tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>A total of 36 studies were identified and evaluated. Eighteen studies investigated their effect in oral infections, seven in infection of the respiratory tract, six in rhino\u2010sinusal diseases, four investigated the use in tonsillectomy and head and neck surgery and one study explored the preventive effect in otitis media. Honey can be considered as effective (additional) treatment in mucositis, childhood cough, persistent post\u2010infectious cough and after tonsillectomy. Propolis may have a role in the treatment of (aphthous) stomatitis, mouth ulcer and prevention of acute otitis media. Royal jelly showed to reduce mucositis. In the presented studies, beehive products proved to be safe, with only minor adverse reactions. Studies showed to be diverse and had some methodological limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12557","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T06:35:58Z","timestamp":1444458958000},"page":"519-531","source":"Crossref","is-referenced-by-count":23,"title":["Honey and beehive products in otorhinolaryngology: a narrative review"],"prefix":"10.1111","volume":"41","author":[{"given":"D.","family":"Henatsch","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Maastricht University Medical Center (MUMC) Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wesseling","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Maastricht University Medical Center (MUMC) Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.W.","family":"Kross","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Maastricht University Medical Center (MUMC) Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Stokroos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Maastricht University Medical Center (MUMC) Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200211000-00008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00185-5"},{"key":"e_1_2_8_4_1","first-page":"22","article-title":"Biological activity of bee propolis in health and disease","volume":"7","author":"Khalil M.L.","year":"2006","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0256135"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.00966.x"},{"key":"e_1_2_8_7_1","first-page":"159","article-title":"Honey: a reservoir for microorganisms and an inhibitory agent for microbes","volume":"7","author":"Olaitan P.B.","year":"2007","journal-title":"Afr. Health Sci."},{"key":"e_1_2_8_8_1","first-page":"124","article-title":"Bugs as drugs, Part 1: insects: the \u201cnew\u201d alternative medicine for the 21st century?","volume":"15","author":"Cherniack E.P.","year":"2010","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2425"},{"key":"e_1_2_8_10_1","first-page":"CD005083","article-title":"Honey as a topical treatment for wounds","author":"Jull A.B.","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734605286014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/109662003322233530"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-004-0871-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/109662003322233549"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2004.7.377"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(03)00092-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.05.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(00)00007-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.68.138"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.04.039"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.03.038"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.046"},{"key":"e_1_2_8_24_1","first-page":"330","article-title":"Additive activity of royal jelly and honey against Pseudomonas aeruginosa","volume":"13","author":"Boukraa L.","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062055b"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf1018164"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0114637"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(02)00406-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00191-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410802615270"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.12.002"},{"key":"e_1_2_8_32_1","first-page":"CD007094","article-title":"Honey for acute cough in children","volume":"3","author":"Oduwole O.","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2008.02304.x"},{"issue":"4","key":"e_1_2_8_34_1","first-page":"CD000978","article-title":"Interventions for preventing oral mucositis for patients with cancer receiving treatment","volume":"13","author":"Worthington H.V.","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_35_1","unstructured":"Review Manager (RevMan) [Computer program]. (2014)Version 5.3. Copenhagen: The Nordic Cochrane Centre The Cochrane Collaboration"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2011.03.005"},{"key":"e_1_2_8_37_1","first-page":"S14","article-title":"Double\u2010blinded, randomized, controlled trial of medicated versus nonmedicated merocel sponges for functional endoscopic sinus surgery","volume":"40","author":"Chang E.H.","year":"2011","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2031-0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2013.00072"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-293"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.3.217"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3075"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-006-0090-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2000.00504.x"},{"key":"e_1_2_8_45_1","first-page":"238","article-title":"Single\u2010blind study of manuka honey in allergic fungal rhinosinusitis","volume":"40","author":"Thamboo A.","year":"2011","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.9246"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/HNP.0000000000000033"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2013.04.002"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3233-x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2013.469"},{"key":"e_1_2_8_51_1","first-page":"1","article-title":"Honey with coffee: a new finding in the treatment of persistent postinfectious cough","volume":"23","author":"Raeessi M.A.","year":"2011","journal-title":"Iran J. Otorhinolaryngol."},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.669026"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.105689"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.05.014"},{"key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00520-003-0443-y","article-title":"Topical application of honey in the management of radiation mucositis. A preliminary study","volume":"11","author":"Biswal B.M.","year":"2003","journal-title":"Support. Care Cancer"},{"key":"e_1_2_8_56_1","first-page":"453","article-title":"The effect of honey on mucositis induced by chemoradiation in head and neck cancer","volume":"110","author":"Maiti P.K.","year":"2012","journal-title":"J. Indian Med. Assoc."},{"key":"e_1_2_8_57_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5005\/jcdp-9-3-40","article-title":"The effect of topical application of pure honey on radiation\u2010induced mucositis: a randomized clinical trial","volume":"9","author":"Motallebnejad M.","year":"2008","journal-title":"J. Contemp. Dent. Pract."},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002478"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/974967"},{"key":"e_1_2_8_60_1","first-page":"29","article-title":"Propolis buccal paste in treatment of aphtous ulceration: formulation and clinical evaluation","volume":"4","author":"Ali H.S.","year":"2011","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1715"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2541"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.12.1140"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0311"},{"key":"e_1_2_8_65_1","first-page":"115","article-title":"Natural propolis extract NIVCRISOL in the treatment of acute and chronic rhinopharyngitis in children","volume":"46","author":"Crisan I.","year":"1995","journal-title":"Rom. J. Virol."},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61996-5"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319821"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.11.036"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.07.001"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2011.07.014"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300219"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17044400"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.02.004"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.03.012"},{"key":"e_1_2_8_75_1","first-page":"CD000978","article-title":"Interventions for preventing oral mucositis for patients with cancer receiving treatment","volume":"00","author":"Worthington H.V.","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1077-x"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017709"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-200211000-00002"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0992-1"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2007.11.004"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.01.005"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2824"},{"key":"e_1_2_8_83_1","first-page":"CD000980","article-title":"Vitamin C for preventing and treating the common cold","volume":"1","author":"Hemila H.","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_84_1","first-page":"CD001831","article-title":"Over\u2010the\u2010counter (OTC) medications for acute cough in children and adults in ambulatory settings","volume":"8","author":"Smith S.M.","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0868"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102010-00003"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.611533"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.12.011"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01049.x"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.05.012"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32801042fa"},{"key":"e_1_2_8_92_1","first-page":"CD001364","article-title":"Zinc for the common cold","volume":"6","author":"Singh M.","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_93_1","first-page":"CD006639","article-title":"Zinc supplements for preventing otitis media","volume":"4","author":"Gulani A.","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1649-5"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2011.5153"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12557","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:35:19Z","timestamp":1695486919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":94,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/coa.12557"],"URL":"https:\/\/doi.org\/10.1111\/coa.12557","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}