{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:23:55Z","timestamp":1789712635498,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Agency of Zhejiang Province, China","award":["2013C33176"],"award-info":[{"award-number":["2013C33176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of direct application of ofloxacin otic drops on human traumatic tympanic membrane perforations (<jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Prospective, sequential allocation, controlled clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>In total, 149 patients with traumatic <jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>s were recruited. They were allocated sequentially to two groups: a conservative observation group (<jats:italic>n<\/jats:italic> = 75) and a ofloxacin drops\u2010treated group (<jats:italic>n<\/jats:italic> = 74).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The closure rate, closure time and rate of otorrhoea were compared between the groups at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 145 patients were analysed. The closure rates of medium perforations between the groups were not significantly different (<jats:italic>P<\/jats:italic> = 0.35); however, the ofloxacin drops\u2010treated group had a significantly shorter closure time for medium perforations than the observation group (<jats:italic>P<\/jats:italic> &lt; 0.01). Additionally, the ofloxacin drops\u2010treated group showed improvement in the closure rate of large perforations (<jats:italic>P<\/jats:italic> = 0.02) and a significantly shorter mean closure time (<jats:italic>P<\/jats:italic> &lt; 0.01) than the observation group. However, purulent otorrhoea was not significantly different between the groups (<jats:italic>P<\/jats:italic> = 0.37).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings indicate that the moist eardrum environment resulting from topical application of ofloxacin drops shortened the closure time and improved the closure rate, but did not affect hearing improvement or increase the rate of middle ear infection of large traumatic <jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>s. Thus, although traumatic <jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>s tend to heal spontaneously, moist therapy can be considered for traumatic, large <jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>s in the clinic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12564","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T08:14:43Z","timestamp":1444810483000},"page":"564-570","source":"Crossref","is-referenced-by-count":31,"title":["The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations"],"prefix":"10.1111","volume":"41","author":[{"given":"Z.","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The Affiliated YiWu Hospital of Wenzhou Medical University Yiwu Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Xinxiang Medical University Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated YiWu Hospital of Wenzhou Medical University Yiwu Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Research Center School of Pharmacy Zhejiang Provincial Key Laboratory of Biotechnology Pharmaceutical Engineering Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2001.11445496"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181690792"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197902000-00009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01764.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31826939b5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02387.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811409836"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.122186"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e31826f5640"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70122-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2689-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200305000-00004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600678797"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860120034003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989811800529"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12614460"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(94)90002-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108003800"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2009.07.002"},{"key":"e_1_2_9_21_1","first-page":"427","article-title":"Simple maneuver for closing traumatic eardrum perforation by micropore strip tape patching","volume":"11","author":"Saito Y.","year":"1990","journal-title":"Am. J. Otolaryngol."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3180dca1a3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1651"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.03.014"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.12.1294"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X121057"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200701000-00013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.Sup3.15546"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09249"},{"key":"e_1_2_9_30_1","first-page":"488","article-title":"Electrical stimulation increases the expression of fibroblast receptors for transforming growth factor\u2010beta","volume":"88","author":"Falanga V.","year":"1987","journal-title":"J. Invest. Dermatol."}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12564","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:34:56Z","timestamp":1695486896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/coa.12564"],"URL":"https:\/\/doi.org\/10.1111\/coa.12564","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}