{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:36:15Z","timestamp":1789256175002,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["10049035"],"award-info":[{"award-number":["10049035"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of a postoperative proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) on voice outcomes after phonomicrosurgery in patients with vocal fold polyp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This is a prospective, randomized controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>This study was carried out in a tertiary care referral medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 48 patients underwent phonomicrosurgery for vocal fold polyps. After surgery, patients were randomized to the <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (lansoprazole 15 mg twice daily for 2 months) and the non\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Voice handicap index (<jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>) and perceptual and acoustic voice analysis were evaluated at baseline and 2 months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 48 enrolled patients, a total of 42 patients [non\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>n<\/jats:italic> = 23), <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>n<\/jats:italic> = 19)] completed the study. The <jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>, perceptual and most acoustic parameters significantly improved in both groups after surgery. However, there was no significant difference in the per cent of change in those parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postoperative <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> treatment did not significantly influence voice outcomes after phonomicrosurgery in patients with vocal fold polyp.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12611","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T02:48:42Z","timestamp":1450838922000},"page":"730-736","source":"Crossref","is-referenced-by-count":13,"title":["Effect of postoperative proton pump inhibitor therapy on voice outcomes following phonomicrosurgery for vocal fold polyp: a randomized controlled study"],"prefix":"10.1111","volume":"41","author":[{"given":"Y.C.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; 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