{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:43Z","timestamp":1761823783294},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Identification at time of diagnosis of those vestibular schwannomas that will not grow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study of consecutive patients diagnosed with a sporadic vestibular schwannoma that were entered in the wait\u2010and\u2010scan protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The study group contained 155 patients with a sporadic vestibular schwannoma first seen in the full 8\u2010year period 2000\u20132007: continual wait\u2010and\u2010scan (<jats:italic>n<\/jats:italic> = 89) and initial wait\u2010and\u2010scan until intervention (<jats:italic>n<\/jats:italic> = 66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Tumour growth, defined as more than 2 mm linear difference in any plane between the diagnostic <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010scan and the last available scan, was related to clinical parameters at diagnosis: localisation of the tumour (solely intracanalicular <jats:italic>versus<\/jats:italic> cisternal extension), sudden sensorineural hearing loss, sensorineural hearing loss longer than 2 years and vertigo\/instability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hearing loss longer than 2 years and an entirely intracanalicular localisation were associated with no tumour growth by univariate and multivariate Cox analysis. Combining both factors at time of diagnosis resulted in a group with low risk of growth (<jats:italic>n<\/jats:italic> = 36, median follow\u2010up of 6.2 years) with a Hazard Ratio for growth of 0.37 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.19\u20130.69). This subgroup is about 25% of the wait\u2010and\u2010scan population. Thirty\u2010one percent showed growth, while in the remaining higher risk group of 119 patients 62% showed growth. For the growing schwannomas, the median time for growth becoming manifest is 1.9 years after diagnostic <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study on vestibular schwannoma patients that start in a wait\u2010and\u2010scan protocol, about a quarter may be set apart having a low risk for growth. These patients at diagnosis combine a history of hearing loss longer than 2 years and a fully intracanalicular schwannoma. They seem to be not needed yearly <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> checks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12661","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T08:06:45Z","timestamp":1460966805000},"page":"788-792","source":"Crossref","is-referenced-by-count":11,"title":["Identifying at diagnosis the vestibular schwannomas at low risk of growth in a long\u2010term retrospective cohort"],"prefix":"10.1111","volume":"41","author":[{"given":"J.G.","family":"Wolbers","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.G.","family":"Dallenga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"van Linge","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"te West","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.E.","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Zaans Medical Centre Zaandam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"M\u00e9ndez Romero","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.K.H.","family":"Pauw","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.","family":"Wieringa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1215\/S1522851705000323"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215041917989"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.3.241"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200503000-00011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.1.0059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01705.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181d279a3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/MAO.0b013e3182595454","article-title":"Growth characteristics of vestibular schwannoma","volume":"33","author":"Moffat D.A.","year":"2012","journal-title":"Otol. Neurotol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200606000-00018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318180a4c4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0791-9"},{"key":"e_1_2_8_13_1","first-page":"495","article-title":"Acoustic tumor growth: implications for treatment choices","volume":"20","author":"Fucci M.J.","year":"1999","journal-title":"Am. J. Otol."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112001206"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200307000-00019"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12661","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:09:44Z","timestamp":1696306184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/coa.12661"],"URL":"https:\/\/doi.org\/10.1111\/coa.12661","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}