{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:02:37Z","timestamp":1790726557111,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the efficacy of endoscopic sinus surgery (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) on olfactory function in chronic rhinosinusitis patients with nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) and without nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) and to compare the nasal obstruction and symptom evaluation (<jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content>) scale before and after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective cohort study<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Royal National Throat and Nose and Ear Hospital, London <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>One hundred and thirteen patients with CRS; 60 CRSwNP and 53 CRSsNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measurements<\/jats:title><jats:p>Olfaction was measured using both the University of Pennsylvania Smell Investigation Test (<jats:styled-content style=\"fixed-case\">UPSIT<\/jats:styled-content>) and the \u2018sense of smell\u2019 visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content> scale, the sinonasal outcome test (<jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content> 22) and the Lund\u2013Kennedy (<jats:styled-content style=\"fixed-case\">LK<\/jats:styled-content>) surgeon reported scores were also measured pre\u2010 and postoperatively at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">UPSIT<\/jats:styled-content> psychophysical measurement significantly improved following <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> subgroup as did the patients perceived <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> sense of smell. However, in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> subgroup, the improved <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UPSIT<\/jats:styled-content> measurements were not significant. The <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SNOT<\/jats:styled-content> 22 and <jats:styled-content style=\"fixed-case\">LK<\/jats:styled-content> scores all improved significantly. The olfactory improvement as measured by the <jats:styled-content style=\"fixed-case\">UPSIT<\/jats:styled-content> correlated to the <jats:styled-content style=\"fixed-case\">SNOT<\/jats:styled-content>\u201022, but a correlation between the <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content> score and <jats:styled-content style=\"fixed-case\">UPSIT<\/jats:styled-content> was not found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endoscopic sinus surgery significantly improved the patient's perceived and measured sense of smell in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> subgroup which is the most surgically responsive <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> subgroup. Additionally, improved olfaction in the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> subgroup is most likely to improve the patient's quality of life. Endoscopic sinus surgery significantly improved the <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content> scale in both <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> subgroups at 6 months following surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12665","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T23:40:02Z","timestamp":1461800402000},"page":"798-803","source":"Crossref","is-referenced-by-count":42,"title":["Outcomes in endoscopic sinus surgery: olfaction, nose scale and quality of life in a prospective cohort study"],"prefix":"10.1111","volume":"41","author":[{"given":"P.J.","family":"Andrews","sequence":"first","affiliation":[{"name":"Department of Rhinology and Facial Plastic Reconstructive Surgery The Royal National Throat Nose &amp; Ear Hospital London UK"},{"name":"The EAR Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010L.","family":"Poirrier","sequence":"additional","affiliation":[{"name":"ENT Department University Hospital of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.J.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Rhinology and Facial Plastic Reconstructive Surgery The Royal National Throat Nose &amp; Ear Hospital London UK"},{"name":"The EAR Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjt072"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bju043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00027"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4193\/Rhino11.213","article-title":"Olfaction after endoscopic sinus surgery: long\u2010term results","volume":"50","author":"Rudolf Briner H.","year":"2012","journal-title":"Rhinology."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21350"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100132967"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3667-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12455"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.049"},{"key":"e_1_2_8_15_1","first-page":"2","article-title":"Functional endoscopic sinus surgery: 5 year follow up and results of a prospective, randomised, stratified, double\u2010blind, placebo controlled study of postoperative fluticasone propionate aqueous nasal spray","volume":"43","author":"Rowe\u2010Jones J.M.","year":"2005","journal-title":"Rhinology."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100128014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1972-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0409-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12463"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834dfb3d"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin14.077"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318170b5cb"},{"key":"e_1_2_8_24_1","first-page":"15","article-title":"Olfactory function after functional endoscopic sinus surgery for chronic sinusitis","volume":"36","author":"Delank K.W.","year":"1998","journal-title":"Rhinology."}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcoa.12665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.12665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:09:48Z","timestamp":1696306188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.12665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/coa.12665"],"URL":"https:\/\/doi.org\/10.1111\/coa.12665","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}