{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:25:44Z","timestamp":1762323944165},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Lymph node ratio (<jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content>) has been shown to be an independent predictor of recurrence risk and survival in different entities of carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective chart review, 128 patients with parotid gland cancer (PGC) subsequently treated by primary surgery were included. About 64% (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) of these patients were additionally treated with adjuvant radiotherapy. Five\u2010year overall survival rates were determined by subgroups based on <jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content> value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lymph node ratio was found to be significantly associated with overall survival rate (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Using univariate analyses, pathological tumour\u2010node\u2010metastasis (<jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content>)\u2010stage, <jats:styled-content style=\"fixed-case\">UICC<\/jats:styled-content>\u2010stage grouping and extracapsular spread were found to be significant predictors of overall survival (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). However, with a multivariate analyses, <jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content> remained the only independent predictor of overall survival (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After surgery for PGC, evaluation of the neck using <jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content> was found to reliably stratify the overall survival rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.12672","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T05:41:44Z","timestamp":1463463704000},"page":"98-103","source":"Crossref","is-referenced-by-count":20,"title":["Prediction of outcome by lymph node ratio in patients with parotid gland cancer"],"prefix":"10.1111","volume":"42","author":[{"given":"M.F.","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of 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